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Volume 6
Journal of Infectious Diseases and Therapy
ISSN: 2332-0877
Infection Congress 2018
March 01-02, 2018
March 01-02, 2018 Berlin, Germany
5
th
International Congress on
INFECTIOUS DISEASES
Toxic-shock syndrome of
Streptococcus pyogenes
(groupAstreptococcus) in pregnancy –Arare entity
Nuryuziliana Dolmat
and
Siti Nadiah Ibrahim
Tawau General Hospital, Malaysia
G
roup A streptococcus (GAS)-induced toxic shock syndrome (TSS) in pregnancy is rare, but its clinical course is fulminant.
Mortality of GAS-induced toxic-shock syndrome is high as 50%. Here, we report two obstetrics cases from South-East
Coast of Sabah, Malaysia. The first case was 23 year old lady presented with preterm labour at 24 weeks. She was in severe
septic shock at presentation that requires three inotropes support. Her condition deteriorate very fast despite broad spectrum
antibiotic and metronidazole, she succumbed within 24 hours from admission. Post mortem was done for her showed tissue
culture from multiple organs grew GAS. While in other case, 23 year old lady at 34 weeks initially presented with shortness
of breath with elevated blood pressure which been treated as acute pulmonary oedema secondary to severe pre-eclampsia.
Her chest X-ray also suggestive of pneumonia was treated with ceftriaxone and azithromycin. An emergency lower segment
caesarean section was done as her condition was worsening, severe metabolic acidosis requiring haemodialysis, difficulty in
maintaining ventilation and needing inotropes to support her blood pressure. Post operatively, she was monitored in intensive
care unit and antibiotics were changed to C-Penicillin and Clindamycin as her blood culture grew GAS which was sensitive to
both. She had good recovery period after completion of antibiotics for 10 days and discharged well home. Unfortunately, both
baby for these two women did not survive. The clinical manifestation is varied thus it is challenging in making diagnosis and
subsequently delivering early management.
Biography
Nuryuziliana Dolmat (Yuzi) is currently working as Obstetrician and Gynecologist at Tawau General Hospital, Tawau Sabah. She completed her Masters of
Obstetrics & Gynaecology from the University of Malaya. She worked at Sabah Women and Children Hospital as a Specialist and then promoted as Head of
Department in Obstetric Department in Tawau General Hospital. She had involved with many teaching session for post graduate student in O&G.
widuri_183@yahoo.comNuryuziliana Dolmat et al., J Infect Dis Ther 2018, Volume 6
DOI: 10.4172/2332-0877-C1-039