industrial-chemistry-2017-keynote

4 / 11

Volume 3, Issue 2 (Suppl) Ind Chem
ISSN: 2469-9764, ICO an open access journa Industrial Chemistry 2017
May 22-23, 2017
Page 26
conferenceseries.com
May 22-23, 2017 Las Vegas, USA
2nd World Conference on
Industrial Chemistry and Water Treatment
Chemoenzymatic synthesis of polysaccharide-grafted polymeric materials
Biological macromolecules, such as polysaccharide and protein (peptide), are vital materials in living systems. Such functions
are appeared by their controlled primary and higher-ordered structures. Furthermore, branched or grafted biological
polymers are often appeared in nature and such complicated structures contribute to exhibiting important in vivo functions.
Accordingly, synthetic method for combining several biological macromolecules into branching or grafting is expected to
produce new functional polymers. On the basis of the viewpoint, we have reported the synthesis of amylose-grafted polymeric
materials by chemoenzymatic approach, which is a combined method of phosphorylase, catalyzed enzymatic polymerization
of α-D-glucose 1-phosphate (G-1-P) monomer for the amylose production with appropriate chemical reactions. The
phosphorylase-catalyzed enzymatic polymerization using G-1-P as a monomer proceeds with the construction of -glycosidic
bond under mild conditions, leading to the direct formation of α(1γ4)-glucan chain, i.e., amylose, in the aqueous media. To
initiate the polymerization, amaltooligosaccharide is required as a primer in the initial reactionmedia.The synthesis of amylose-
grafted heteropolysaccharides has been performed by combining the phosphorylase-catalyzed enzymatic polymerization
with the appropriate chemical reaction (chemoenzymatic method). For example, amylose-grafted carboxymethyl cellulose
(CMC) was synthesized as the following chemoenzymatic method. A maltooligosaccharide having an amino group was first
introduced to the CMC by using condensing agent. Then, the phosphorylase-catalyzed enzymatic polymerization of G-1-P
from the maltooligosaccharide chain ends on the product was performed to obtain the desired amylose-grafted CMC. The
product had the rigid CMC main chain, which further assembled, leading to nanofibers by the formation of double helix
between the long amylose graft chains in the intermolecular CMC chains. The chemoenzymatic synthesis of amylose-grafted
poly γ-glutamic acid (PGA) as a new artificial polysaccharide-polypeptide conjugate was also investigated. The product formed
a robust hydrogel, which could be converted into a regularly controlled porous material.
Biography
Jun-Ichi Kadokawa holds PhD degree in Engineering. Currently, he is a Professor of Chemistry, Biotechnology and Chemical Engineering at Kagoshima University, Japan.
He studied applied chemistry and materials chemistry at Tohoku University, where he received his MS degree in 1989 and PhD in 1992. He has then joined Yamagata
University as a Research Associate. From 1996 to 1997, he has worked as a Visiting Scientist at the Max-Planck-Institute for Polymer Research in Germany. In 1999,
he became an Associate Professor at Yamagata University and moved to Tohoku University in 2002. He was appointed as a Professor of Kagoshima University in 2004.
His research interests focus on enzymatic synthesis of functional oligo- and polysaccharides and control of their higher-ordered structures. He has received the award for
Encouragement of Research in Polymer Science (1997) and the Cellulose Society of Japan award (2009).
Jun-Ichi Kadokawa
Kagoshima University, Japan
Jun-Ichi Kadokawa, Ind Chem 2017, 3:2 (Suppl)
Notes: