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Volume 6, Issue 6 (Suppl)
Med Aromat Plants
ISSN: 2167-0412 MAP, an open access journal
Herbals Summit 2017
October 18-20, 2017
October 18-20, 2017 Osaka, Japan
3
rd
Global Summit on
Herbals & Traditional Medicine
Bioactivity of selected medicinal plants used for the treatment of sexually transmitted diseases
T E Tshikalange and P B Mamba
University of Pretoria, South Africa
S
exually transmitted diseases have a major impact on sexual and reproductive health worldwide. Each year, the World
Health Organization estimates 448 million new cases of curable STD’s are diagnosed. Ethanol extracts of 12 South African
medicinal plants used in the treatment of STD’s and 3 flavonoids were investigated for their antimicrobial activity against
Candida albicans, Gardnerella vaginalis, Neisseria gonorrhoeae
and
Oligella ureolytica
. The anti-inflammatory activities of the
extracts and compounds were determined by measuring the inhibitory effect of the extracts and compounds on the pro-
inflammatory enzyme lipoxygenase. The extracts and compounds were also investigated for their anti-HIV activities against
recombinant HIV-1 enzyme using non-radioactive HIV-RT colorimetric assay.
Acacia karroo
and
Rhoicissus tridentata
extracts
showed good antimicrobial activity with MIC values ranging between 0.4 and 3.1 mg/ml. Extracts of
Jasminum fluminense,
Solanum tomentosum
and flavonoids 2 and 3 had good anti-inflammatory activity with IC
50
less than the positive control,
quercetin (IC
50
=48.86 ug/ml).
A. karroo
and flavonoid 3 exhibited moderate HIV-1 RT inhibition activity of 66.8 and 63.7%,
respectively.
R. tridentata
and
Terminalia sericea
had the best RT inhibition activity (75.7% and 100%) compared to that
of the positive control Doxorubicin (96.5%) at 100 ug/ml concentration. The emergence of drug resistance in STD related
microorganisms and potential side effects demand the discovery of newer drugs. The exploration of newer anti-microbial
substances from natural sources may serve as promising alternatives. The observed activities may lead to new multi-target
drugs against sexually transmitted diseases.
Biography
T E Tshikalange is currently a Senior Lecturer in the Department of Plant and Soil Sciences of the University of Pretoria in South Africa. His research focus areas
include ethno-botanical medicinal plants used traditionally in the treatment of sexually transmitted diseases, oral pathogens and antimicrobial activities. He has
published articles in peer reviewed national and international journals and has been serving as an Editorial Board Member of
BMC Complementary and Alternative
Medicine
. He has co-authored chapters in the book
Medicinal Plant Research in Africa: Pharmacology and Chemistry.
emmanuel.tshikalange@gmail.comT E Tshikalange et al., Med Aromat Plants 2017, 6:6 (Suppl)
DOI: 10.4172/2167-0412-C1-014