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.com
Volume 6, Issue 6 (Suppl)
Med Aromat Plants
ISSN: 2167-0412 MAP, an open access journal
Herbals Summit 2017
October 18-20, 2017
October 18-20, 2017 Osaka, Japan
3
rd
Global Summit on
Herbals & Traditional Medicine
Hypnotic and general anesthetic effects of
Citrus aurantium
L. oil on rats
Khaled Abo-El-Sooud
Cairo University, Egypt
Background & Aim:
Central Nervous System (CNS) depressant drugs have many negative side effects including addiction,
depression, suicide, convulsion, sexual dysfunction, headaches and amore. Moreover, these agents do not restore normal levels
of neurotransmitters but instead influence the brain chemistry. In contrast to drugs, a number ethno-botanical products have
been identified which reduce anxiety by re-establishing by altering both neurotransmitter levels in the absence of the severe
side effects. The bitter orange fruit (
Citrus aurantium
) contains a number of phytochemicals of interest known to increase the
production of dopamine. The purpose of this study is to evaluate
Citrus aurantium
L., oil ability to induce sedative/hypnotic
and/or general anesthetic effects in experimental models.
Methodology & Theoretical Orientation:
Essential oil from peel was obtained by steam distillation, then maintained and
protected against light and heat until the pharmacological assays. The main component of the oil was determined by GC-MS.
The LD
50
of the oil was determined to calculate the therapeutic dose. Experimental models were performed in this study to
evaluate the hypnotic and anesthetic effects of C.
aurantium
as compared with thiopental sodium at a dose of (30 mg kg
-1
) after
Intra-Peritoneal injection (I/P).
Findings:
The LD
50
of the oil was 300 mg kg
-1
of body weight after intra-peritoneal injection (I/P). The main component of the
EOP was D-limonene. The CNS depressant effect of C.
aurantium
oil is dose dependent. At small dose there was an induction
of hypnosis as righting reflex was absent with ataxia. At higher doses the oil induced anesthesia at 8 min and the consciousness
is regained in about 25 minutes.
Conclusion & Significance:
The use of animal model of hypnotic and ultra-short general anesthetic of
C.
aurantium
oil
significantly supports its use an adjunct for the treatment of insomnia and other CNS disorders.
Recommendations:
Further evaluations are required to elucidate the detailed mechanism of CNS depressant activity and
possible side effects of
Citrus aurantium
and the possibility of its use as alternative natural general anesthetic agent.
Biography
Khaled Abo-El-Sooud is currently a Professor of Pharmacology in Cairo University, Egypt. He has his expertise in radioisotopes and chromatography (GC-HPLC-
TLC etc.) for detection of drug residues.
kasooud@cu.edu.egKhaled Abo-El-Sooud, Med Aromat Plants 2017, 6:6 (Suppl)
DOI: 10.4172/2167-0412-C1-014