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Volume 6, Issue 6 (Suppl)
Med Aromat Plants
ISSN: 2167-0412 MAP, an open access journal
Herbals Summit 2017
October 18-20, 2017
October 18-20, 2017 Osaka, Japan
3
rd
Global Summit on
Herbals & Traditional Medicine
Cycloartobiloxanthone extracted from bark of
Artocarpus gomezianus
inhibits the migratory behavior
of non-small cell lung cancer cells
Sucharat Tungsukruthai and Pithi Chanvorachote
Chulalongkorn University, Thailand
L
ung cancer metastasis is one of the most common causes of cancer death. The process requires tumor cell dissemination,
motility, intravasation and formation of new tumor at different sites. Natural product-derived compounds exhibiting anti-
motility effects is of interest as theymay serve as promising lead compounds for cancer therapy.This research aimed to investigate
the effect of cycloartobiloxanthone, a pure compound isolated from bark of
Artocarpus gomezianus
on migration and invasion
activities of non-small cell lung cancer cells. Cells were treated with various concentrations of the compound to determine cell
viability using MTT assay. The migration and invasion of the treated cells were evaluated by wound healing and trans-well
assays, respectively. Motility-related proteins were investigated by western blotting. Here we found that cycloartobiloxanthone
exhibited potent anti-migration and anti-invasion activities tested in lung cancer H460 cells. In addition, results showed that
the compound suppressed cell migration by attenuated migration regulatory proteins. Together, the inhibitory activity of
cycloartobiloxanthone on lung cancer migration suggests that cycloartobiloxanthone may be suitable for further development
for the treatment of cancer metastasis.
Biography
Sucharat Tungsukruthai has completed her Bachelor’s degree in Science (Biology) from Chulalongkorn University in 2016. She has completed her Master’s degree in Pharmacology
and currently a Training Researcher at Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Thailand.
She is interested in special pathways in cancer such as apoptosis, metastasis and autophagy.
chequeiiz@gmail.comSucharat Tungsukruthai et al., Med Aromat Plants 2017, 6:6 (Suppl)
DOI: 10.4172/2167-0412-C1-014