herbals-summit-2017-scientifictracks-abstracts

23 / 25

Page 49
Notes:
conferenceseries.com
Volume 6, Issue 6 (Suppl) Med Aromat Plants
ISSN: 2167-0412 MAP, an open access journal Herbals Summit 2017
October 18-20, 2017
October 18-20, 2017 Osaka, Japan
3rd Global Summit on
Herbals & Traditional Medicine
Cardio-protective effect of Salvianic acid A in db/db mice with elevated homo-cysteine level
Lei Gao1, Christopher Wk Lai1, Yiu-Wa Kwan2 and Adelheid Brantner 3
1Hong Kong Polytechnic University, Hong Kong
2Chinese University of Hong Kong, Hong Kong
3University of Graz, Austria
C ardiovascular disease is the top death cause in people with diabetes, particularly in individuals with elevated Homo-
cysteine (Hcy) level. Left ventricular hypertrophy and endothelial dysfunction are critical signs of heart disease and
vascular disorder respectively in diabetics. Salvianic Acid A (SAA) is a major active ingredient extracted from a typical
traditional Chinese medicine applied in treatment of cardiovascular disease. In this study, we investigated the protective effects
of SAA on left ventricular hypertrophy and endothelial dysfunction in db/db mice with elevated Hcy level and to decipher
whether the cardio-protective effects of SAA involve the modulation of methylation potential and improvement of redox
status in liver. Our results suggested that chronic administration of SAA suspended left ventricular hypertrophy within the
intervention period (2.9% increase of left ventricular mass in SAA-treated group compared to 49.0% increase of left ventricular
mass in group without treatment) and ameliorated endothelial dysfunction in db/db mice (improve endothelial-dependent
vasorelaxation by 42.8% in SAA-treated group compared to group without SAA treatment). The acute vaso-relaxant effects
of SAA were also assessed in ex vivo assay. Besides, the serum Hcy level in group with SAA treatment was found significantly
decreased 40.8% compared to diabetes group without SAA. These observed cardio-protective effects of SAA are probably due
to improved redox status induced by the antioxidant effect of SAA itself and to the increased production of glutathione (23.2%
increase in SAA-treated group compared to group without SAA treatment) via up-regulation of trans-sulfuration pathway
during the Hcy metabolism in liver.
Biography
Lei Gao has completed his Master’s degree of Medicine at Shandong University of Traditional Chinese Medicine, China in 2011. He was awarded the Eurasia-Pacific-Ernst Mach
Scholarships in 2016 and is currently a PhD candidate.
Lei Gao et al., Med Aromat Plants 2017, 6:6 (Suppl)
DOI: 10.4172/2167-0412-C1-014