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Volume 5, Issue 4 (Suppl) Occup Med Health Aff
ISSN: 2329-6879 OMHA, an open access journal Health Congress 2017
October 16-17, 2017
October 16-17, 2017 Dubai, UAE
12th World Congress on
Industrial Health, Healthcare and Medical Tourism
DNA damage biomarkers: How do they predict susceptibility, exposition and effects? From in vitro
evaluations to human bio-monitoring and health promotion
Raquel Alves dos Santos
University of Franca, Brazil
There are a great number of genetic biomarkers to evaluate the effects of a single or multiple compounds. While OECD
(Organization for Economic Cooperation Development) predicts genotoxicity assessment as part of toxicological
evaluation of natural compounds, drugs, pesticides, nanomaterials, etc. Great progress has also been made to assess the effects
of exposition in human populations at cellular and molecular levels. The search for the correct genetic biomarker results in
the understanding of how exposure affects the genomic stability as well as how the genetic background modulates the cellular
responses to exposure. This presentation will discuss the use of chromosomal aberration, micronuclei, comet assay, genetic
polymorphisms and gene expression as part of in vitro genotoxicological evaluation of natural compounds (kaurenoic acid,
hinokinin), pesticides (rotenone), biomaterials (poly-lactic acid, nanocellulose-collagen-apatite composite), nanomaterials
(carbon nanotubes, PLGA) and metals (aluminum), as well as the use of these biomarkers to assess genomic instability in
pesticide-exposed populations, breast cancer diagnosed women and type-2 diabetes patients. The presentation will also discuss
how all this knowledge can be translated into practice via exposure/disease prevention and health promotion strategies based
on early genome instability detection.
Recent Publications
1.Nepomuceno R, Villela B S, Corbi SCT, Bastos A S, Santos R A, Takahashi C S, Orrico S, Scarel-Caminaga R M (2017) Dyslipidemia rather than diabetes mellitus or chronic
periodontitis affects the systemic expression of pro-and anti-inflammatory genes.Mediators Inflamm: 1491405.
2.Saska S, Teixeira L N, de Castro Raucci L M S, Scarel-Caminaga R M, Franchi L P, Dos Santos R A, Santagneli S H, Capela M V, de Oliveira P T, Takahashi C S, Gaspar A M M,
Messaddeq Y, Ribeiro S J L, Marchetto R (2017) Nanocellulose-collagen-apatite composite associated with osteogenic growth peptide for bone regeneration. Int J Biol Macromol;
103: 467-476.
Biography
Raquel Alves dos Santos has her expertise in DNA damage and genomic instability related to occupational exposure, non-transmissible chronic diseases and
cancer.
Raquel Alves dos Santos, Occup Med Health Aff 2017, 5:4 (Suppl)
DOI: 10.4172/2329-6879-C1-037