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Volume 5, Issue 4 (Suppl) Occup Med Health Aff
ISSN: 2329-6879 OMHA, an open access journal Health Congress 2017
October 16-17, 2017
October 16-17, 2017 Dubai, UAE
12th World Congress on
Industrial Health, Healthcare and Medical Tourism
Oxidative stress and genetic susceptibility among farmers occupationally exposed to organophosphate
pesticides
Mohamamad Fareed1, 2, Chandrasekharan Nair Kesavachandran2 and Abdullah Tawfik Khoja1
1Imam Muhammad ibn Saud Islamic University, KSA
2CSIR-Indian Institute of Toxicology Research, India
Statement of the Problem: During agricultural work practices, spraying of pesticides without following any protective
measures lead to various adverse health effects among farmers.
Methodology & Theoretical Orientation: A case control study was performed among 52 male pesticide sprayers working
in mango orchards of Lucknow district in a northern state of India, compared with 30 control subjects. Pesticide sprayers
were selected on the basis of clinical examination for acute and chronic health symptoms associated with pesticide exposure.
Among those pesticide sprayers who reported these symptoms, investigation of oxidative stress parameters and genetic
polymorphism of Paraoxonase 1 gene (PON1) for the assessment of intra individual susceptibility for organophosphate
pesticides was performed. Cholinesterase level as biomarker of OP pesticides was investigated to ensure the exposure among
pesticide sprayers.
Findings: Clinical examination of pesticide sprayers showed some acute and chronic symptoms for different organ systems.
Activities of acetylcholinesterase and butyrylcholinesterase were found to be significantly depleted (p<0.05) among pesticide
sprayers as compared to controls. Activity of blood CAT was found to be higher but not found to be statistically significant;
activity of blood GPx was found to be significantly higher (p<0.05); blood GSHwas found to be significantly decreased (p<0.05);
blood MDA level was found to be more in pesticide sprayers as compared to control subjects. A decrease in the percentage of
high-activity genotypes at both L55M and Q192R was observed in the farm workers reporting symptoms of pesticide toxicity.
Conclusion & Significance: Our study shows that occupational exposure of OP pesticides lead to alterations in anti-oxidants
enzymes, eventually leading to the oxidative stress condition. PON1 gene polymorphisms influence the susceptibility of OP
pesticides, hence it may be considered a useful biomarker of genetic susceptibility for the assessment of inter individual risk of
OP pesticide exposure.
Recent Publications
1.Mohammad Fareed, Nasir Salam, Abdullah T Khoja, Mahmoud Abdulrahman Mahmoud and Maqusood Ahamed (2017) Life Style Related Risk Factors of Type 2 Diabetes
Mellitus and Its Increased Prevalence in Saudi Arabia: A Brief Review. International Journal of Medical Research and Health Sciences; 6(3): 125-132.
2.Mohammad Fareed, Chandrasekharan Nair Kesavachandran, Vipin Bihari, Ritul Kamal and Mohammed Kuddus (2017) Oxidative stress and cholinesterase depression among
farm workers occupationally exposed to pesticides in India. Journal of Environmental Biology; 38(2): 305-311.
Biography
Mohammad Fareed is currently working as an Assistant Professor in College of Medicine at Al Imam Mohammad ibn Saud Islamic University in Saudi Arabia. He
has research experience in environmental health and occupational toxicology at Indian Institute of Toxicology Research, India, where he has completed his PhD.
His research interest is life style and environmental risk factors in the pathogenesis of some metabolic diseases. He has published 16 papers in various journals
of international repute and 17 abstracts.
Mohamamad Fareed et al., Occup Med Health Aff 2017, 5:4 (Suppl)
DOI: 10.4172/2329-6879-C1-037