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Volume 8 Journal of Gastrointestinal & Digestive System GI Diseases 2018
July 11-12, 2018
Page 26
conferenceseries.com
July 11-12, 2018 Sydney, Australia
15th International Conference on
Digestive Disorders and Gastroenterology
Risk factors associated with the severity of acute hepatitis A by phase
Sangheun Lee1, Young Hoon Choi1, 2, Ki Jun Han1, Ja Sung Choi1, Jin Woo Park1 and Hyun-Jeong Han2
1Catholic Kwandong University College of Medicine, Republic of Korea
2Myoung Ji Hospital, Republic of Korea
Introduction: Acute hepatitis A (AH-A) is one of the most common forms of viral hepatitis, and distinct clinical features are
associated with the prodromal, icteric and recovery phases. This study was designed to investigate the correlations of various
clinical parameters with severity in AH-A patients in each of these three phases.
Methods: The medical records of 455 patients diagnosed with AH-A were retrospectively reviewed. The prodromal, icteric and
recovery phases were defined by the patterns of changes observed after admission in aspartate aminotransferase (AST), alanine
aminotransferase (ALT) and bilirubin levels. Clinical parameters, including phosphate levels, were analyzed to identify their
associations with the peak levels of AST, ALT and bilirubin.
Results: Of the patients, 129 (28.4%) were admitted in the prodromal phase, 187 (41.1%) in the icteric phase and 139 (30.5%)
in the recovery phase. Phosphate levels showed an inverse relationship with the peak AST and ALT levels in the prodromal
phase (P=0.011 and P=0.005, respectively). Prothrombin time (PT, %) showed a negative relationship with peak AST levels
throughout the prodromal, icteric and recovery phases (P=0.039, P=0.028 and P=0.001, respectively), the peak ALT level in the
prodromal phases (P=0.038) and the peak bilirubin level in the icteric phase (P=0.029).
Conclusion: In conclusion, the baseline phosphate, AST, and ALT levels, as well as PT and the platelet count, were correlated
with the peak levels of AST, ALT and bilirubin in patients with AH-A.
Biography
Sangheun Lee has completed his MD and PhD from Catholic Kwandong University. He is a Doctor in St. International Mary’s Hospital, Catholic Kwnadong
University in Korea. He has published more than 20 papers in reputed journals and has been serving as an Editorial Board Member of repute.
Sangheun Lee ., J Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C2-068