4 / 12
Page 26
Notes:
conferenceseries
.com
Volume 7, Issue 5 (Suppl)
J Gastrointest Dig Syst, an open access journal
ISSN:2161-069X
Gastroenterology 2017
November 13-14, 2017
November 13-14, 2017 | Las Vegas, USA
13
th
International Conference on
Clinical Gastroenterology, Hepatology and Endoscopy
Effect of long term PPI administration on gastric mucosal atrophy: Ameta-analysis
Jin Feng
and
Zhong Li
The Third Affiliated Hospital of Soochow University, China
Background:
Proton pump inhibitors (PPIs) are widely used for the treatment of acid-related gastrointestinal diseases. Recently,
some studies have reported that PPIs can alter the gastric mucosal architecture, but the relationship remains controversial. This meta-
analysis study was designed to quantify the association between long-term PPI administration and gastric atrophy.
Methods:
A computerized search of PubMed was conducted to identify studies using the keywords (proton pump inhibitors OR
PPI) and (gastric atrophy OR atrophic gastritis), published up to May 2016. Heterogeneity among studies was tested with the Q test,
odds ratios (OR) and 95% confidence intervals (CI) ware calculated. P values were calculated by I² tests and regarded as statistically
significant when <0.05.
Result:
We identified 13 studies which included 1465 patients under long-term PPI therapy and 1603 controls, with a total gastric
atrophy (GA) rate of 14.50%. There was a statistically significantly higher presence of GA (15.84%) in PPI group compared to the
control group (13.29%), (OR: 1.55, 95% CI: 1.00–2.41).
Conclusions:
The pooled data suggest that long-term PPI use is associated with increased rates of gastric atrophy. Large-scale
multicenter studies should be conducted to further investigate the relationship between acid suppressants and precancerous disease.
feng7397@sina.comJin Feng et al., J Gastrointest Dig Syst 2017, 7:5 (Suppl)
DOI: 10.4172/2161-069X-C1-055