gastroenterology-2016_posters-accepted-abstracts

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Gastroenterology 2016

September 12-14, 2016

Volume 6, Issue 5(Suppl)

J Gastrointest Dig Syst 2016

ISSN:2161-069X JGDS, an open access journal

conferenceseries

.com

September 12-14, 2016 Atlanta, USA

Global Congress on

Gastroenterology & Endoscopy

“The Hidden Evil”- GI bleed and small bowel obstruction caused by carcinoid tumor found during

exploratory laparotomy

Parminder Minhas

Abington Jefferson Health, USA

ntestinal carcinoid tumors are uncommon malignancies which grow slowly, and rarely cause any symptoms. Small bowel

tumors can, at times, cause bowel obstruction and rarely bleeding. We present to you a 52 year old male who presented to

the hospital for evaluation of melena. His endoscopy and colonoscopy came back negative and patient unfortunately, failed to

get capsule endoscopy as an outpatient. One year later, patient presented with excruciating abdominal pain and was found to

have small bowel obstruction with multiple transition points. Patient was found to have 4 nodular lesions in the small intestine

which were found to be carcinoid tumor. Surgical resection definitely improved his outcome and patient did not need adjuvant

therapy post-surgery. This patient was a diagnostic challenge due unusual presentation and negative CT scan imaging during

both presentations. Carcinoid tumors are highly infiltrating tumors hence, high degree of suspicion should be kept for earlier

detection and better outcome.

J Gastrointest Dig Syst 2016, 6:5(Suppl)

Role of vitamin D deficiency, C- reactive protein and adhesion molecules in severity of ulcerative colitis

Romany Helmy Thabet, Abdullah Zidane Al-Shammari

and

Youssef Nasif Al-Shammari

Northern Borders University, Saudi Arabia

lcerative colitis (UC) is a chronic inflammatory bowel disease (IBD). The hallmark of UC lesions is infiltration of the

intestine by mononuclear cells, predominantly lymphocytes. There is growing epidemiological evidence that suggest

implication of vitamin D deficiency in the development of IBD and also its influence on disease severity. C-reactive protein

(CRP) levels are often used in the follow-up of patients with IBD. Adhesion molecules such as intercellular adhesion molecule

(ICAM) and E-selectin are cell surface-expressed glycoproteins that play a prominent role in leukocyte recruitment and

proliferation in the inflamed colon. The aim of the present descriptive study is to investigate the role of vitamin D, CRP and

the adhesion molecules ICAM and E-selectin in prediction of severity of UC. Samples of blood were taken from 24 diagnosed

cases of UC for measurement of serum levels of vitamin D, CRP, ICAM and E-Selectin by enzyme-linked immunosorbent assay

(ELISA). Severity index for UC cases and its correlation with the aforementioned measures was determined. Comparing to

control groups formed by individuals without clinical and/or laboratory signs of UC, UC patients showed significant increased

levels (p<0.001) of sICAM-1, E-selectin and CRP in serum samples. On the contrary, vitamin D levels were significantly

decreased in UC patients. Strong correlation was statically determined between vitamin D deficiency, CRP, adhesion molecules

and UCEIS. In conclusion, the present work confirmed the role of vitamin D deficiency, adhesion molecules notably ICAM

and E-selectin and the acute phase biomarker CRP in pathogenesis of UC.