gastroenterology-2016_posters-accepted-abstracts

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Gastroenterology 2016

September 12-14, 2016

Volume 6, Issue 5(Suppl)

J Gastrointest Dig Syst 2016

ISSN:2161-069X JGDS, an open access journal

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September 12-14, 2016 Atlanta, USA

Global Congress on

Gastroenterology & Endoscopy

Genetics of inflammatory bowel disease

Inga Peter

Icahn School of Medicine at Mount Sinai, USA

rohn’s disease (CD) and ulcerative colitis are inflammatory conditions, collectively referred to as inflammatory bowel

disease (IBD), which results from defects in the regulation of mucosal immune responses to enteric bacteria in genetically

susceptible individuals. Multiple lines of evidence suggest a genetic contribution to the pathogenesis of IBD, which include

racial and ethnic differences in disease prevalence, familial aggregation and link to other genetic syndromes. Recent genome-

wide association studies (GWAS) have identified >200 genetic variants associated with IBD risk, some of which have functions

in biological pathways of pathogen recognition, internalization and autophagy. However, GWAS-identified loci have explained

less than a quarter of the heritability estimated for IBD and many are confined to noncoding regions, requiring further studies

to understand their role in disease pathogenesis. Recently, next generation sequencing efforts, most successful in isolated

populations and individuals with early age of onset and/or significant family history of IBD, identified rare coding variants

associated with IBD risk that are more amenable to functional studies than GWAS loci. Also, a number of genetic variants

have been linked to adverse events resulting from IBD therapies, particularly thiopurine exposure, including bone marrow

toxicity and pancreatitis. Yet, despite substantial progress in the field of genetics and genomics of IBD, reliable tools to identify

individuals at risk, determine disease progression and predict response to therapies are still lacking. More comprehensive

approaches that incorporate clinical, genetic, epigenetic, metabolomic, and microbiome data need to be developed to allow for

an early diagnosis and personalized treatment for IBD.

Evaluation of the impact of pre & post-transplant metabolic derangements on the neurological

complications following liver transplantation

Mohamed Mohamed Bassam Faek Mohamed Hashem

Cairo University, Egypt

eurologic complications after liver transplantation are a major source of morbidity and mortality and proper prediction

for those at risk may help in improving the outcome. The results of our study showed that severity of end stage liver

failure prior to transplantation might be the most common risk factor for the development of post-transplant neurological

complications and careful evaluation of other risk factors may be required for those patients in order to decrease the

incidence of complications. Still the use of Tacrolimus is associated with risk of neurological complications and reduction or

discontinuation of Tacrolimus lead to improvement of neurological complications. According to our study, electrolytes and

metabolic derangements are not risk factors for development of neurological complications. Although the risk of neurological

complications in our series is high but there was no impact on the survival.

J Gastrointest Dig Syst 2016, 6:5(Suppl)