23 / 27
Page 68
Notes:
conferenceseries
.com
Volume 7, Issue 7 (Suppl)
J Gastrointest Dig Syst
ISSN: 2161-069X JGDS, an open access journal
Gastroenterologists 2017
December 14-15, 2017
December 14-15, 2017 Dubai, UAE
11
th
World
Gastroenterologists Summit
Evaluation of the prescription pattern of proton pump inhibitors and the associated adverse drug
reactions in the medicine unit of a secondary care hospital, Ras-al-Khaimah (RAK), United Arab
Emirates (UAE)
Sukaina Salim Damji
Ras-al-Khaimah Medical and Health Sciences University, UAE
T
he inappropriate prescription pattern of Proton Pump Inhibitors (PPIs) continues to rise every year despite extensive
literature addressing inappropriate utilization. This is significantly associated with drug-related problems (adverse drug
reactions and drug-drug interactions). An observational, prospective study was carried out involving patients of age 18 and
greater, admitted in the medicine ward of IBOH, RAK, UAE and who were prescribed with PPIs. Patients were monitored
by the investigator, participating in the wards rounds with the clinician and relevant details was accessed through WAREED
and documented in the patient profile form. All ADRs observed was confirmed by the physician and documented in the
ADR forms. The ADRs scales utilized were: Naranjo, WHO, Hartwigs, Modified Schumock and Thornton’s scale. Identified
drug-drug interactions were graded based on the severity and the documentation was as per the Micromedex database 2.0.
Statistical analysis was performed using SPSS version 20.0 and a total of 172 patients were studied. The predominant gender
was female and 83 patients were in the age group of >58 years. The PPIs prescribed were; Pantoprazole (n=148), Esomeprazole
(n=10), Rabeprazole and Omeprazole. An appropriate use of PPIs was found to be 37% whereas its inappropriate use was 63%.
Five patients received the inappropriate dose of PPIs. Three clinically insignificant ADRs were observed in 5 patients with the
use of Pantoprazole. No drug-drug interactions were observed. Majority of the prescriptions were not in line with the NICE
guidelines utilized in the study site, in terms of its appropriateness. Our findings suggest the need for frequent prescription
evaluation; institutional protocols and communication between a clinical pharmacist and a physician are crucial approaches.
sucaynadamji@hotmail.comJ Gastrointest Dig Syst 2017, 7:7 (Suppl)
DOI: 10.4172/2161-069X-C1-062