gastroenterologist-2016_scientifictracks-abstracts

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Gastro 2016

August 11-12, 2016

Volume 6, Issue 4(Suppl)

J Gastrointest Dig Syst 2016

ISSN:2161-069X JGDS, an open access journal

conferenceseries

.com

August 11-12, 2016 Birmingham, UK

Global Gastroenterologists Meeting

Hasan Ahmed El-Garem, J Gastrointest Dig Syst 2016, 6:4(Suppl)

Hepatitis C virus infection in Egypt

Hasan Ahmed El-Garem

Cairo University, Egypt

gypt has the highest prevalence of hepatitis C virus infection in the world. The prevalence of HCV viremia was estimated

to be 7.3%, and 90% of them have genotype 4. Until 2007, hepatitis C virus treatment was not offered by the government.

In 2007, an Egyptian National Committee for Control of Viral Hepatitis (NCCVH) has been established. Number of patients

treated with PEG-INF and ribavirin was 350,000. A further step in treating HCV was FDA approval of Sofosbuvir in 2013.

Egyptian government made an agreement with the manufacturer company Gilead to decrease the cost of the course for 3

months from 84000$ to 900$. New treatment protocol started in September 2014. The protocol categorized patients into 2

groups: Group 1 - Patients who were eligible to receive interferon were treated with daily Sofosbuvir (400 mg) and weight-

based ribavirin plus weekly peginterferon for 12 weeks and Group 2 - Patients who were not eligible to receive interferon were

treated by daily sofosbuvir (400 mg) plus weight-based ribavirin for 24 weeks. A further step in treating HCV was achieved

after availability of the new drugs, daclatasvir and ritonavir boosted paritaprevir/ombitasvir in Egypt. Treatment protocol

was updated in November 2015. Patients were categorized into 4 groups: 1 - Easy to treat group, was treated by the following

regimen for 12 weeks; sofosbuvir (400 mg) plus daclatasvir (60 mg). 2 - Difficult to treat group, was treated by the following

regimen for 12 weeks; sofosbuvir (400 mg) plus daclatasvir (60 mg) plus ribavirin (600 mg up to 1000 mg). 3 - Third regimen

was for patients with post organ transplantation and patients who failed previous sofosbuvir containing regimen. These patients

were treated by the following regimen for 24 weeks; sofosbuvir (400 mg) plus daclatasvir (60 mg) plus ribavirin (600 mg up to

1000 mg). 4 - Fourth regimen for patients with glomerular filtration rate less than 30 ml/min were treated by ritonavir boosted

paritaprevir/ombitasvir plus ribavirin for 12 weeks. Results of treatment will be mentioned in the presentation.

Biography

Hasan Ahmed El-Garem has completed his MD from Faculty of Medicine, Cairo University and Post-doctoral studies from Amsterdam Medical Centre. He is a

Professor of Gastroenterology & Hepatology at Faculty of Medicine, Cairo University. He has published more than 25 papers in reputed journals.