gastroenterologist-2016_scientifictracks-abstracts

21 / 50

Notes:
Page 36
Gastro 2016
August 11-12, 2016
Volume 6, Issue 4(Suppl) J Gastrointest Dig Syst 2016
ISSN:2161-069X JGDS, an open access journal
conferenceseries .com
August 11-12, 2016 Birmingham, UK
6th Global Gastroenterologists Meeting
Shahira El-Etreby et al., J Gastrointest Dig Syst 2016, 6:4(Suppl)
Validation of plasma proteasome as a tumor biomarker for diagnosis of hepatocellular carcinoma
Shahira El-Etreby, Ahmed zaid, Monir Bahgat, Salah Al-Gamal, ManalAbd Elhamid, SherinAbd El-Azi, Hosam Zaghloul, Metwally Mortada, Mohamed
El-Rakhawy and Gehan Mazroa
Mansoura University, Egypt
Background & Aim: Early diagnosis of Hepatocellular Carcinoma (HCC) improves prognosis. While many studies revealed
that alpha-fetoprotein (AFP) is a poor HCC biomarker, more recent studies nominated Plasma Proteasome (PP) as a promising
one. So, our aim is to evaluate diagnostic accuracy of PP level as a tumor biomarker for diagnosis of early HCC in Egyptian
patients with liver cirrhosis and to validate it on a large population.
Methods: This study enrolled 120 patients with hepatitis C virus related cirrhosis (60 with HCC and 60 without HCC) versus
60 healthy controls. HCC patients were subdivided into 3 groups according to tumor burden. PP level and AFP were assessed.
Then, validation of these results on large number of HCC population (308 cases) was done.
Results: It was observed that, 200 ng/ml of AFP showed sensitivity for only 40.1%. On the other hand, AUC of PP was 0.883
(0.829-0.938), with cutoff value of 1.1 μg/ml having sensitivity of 98.3%, and specificity of 71.25%. There was no statistically
significant correlation between the level of PP and tumor size, portal invasion or tumor stage (p values = 0.89, 0.07, and 0.82,
respectively). Validation of these results on 308 patients yielded sensitivity of 95.12% and specificity of 60%.
Conclusions: PP level could be a promising biomarker for early HCC diagnosis in cirrhotic patients.
Biography
Shahira El-Etreby has done her specialization in Internal Medicine in the year 2006. Currently, she is an Assistant Professor in Hepatology and Gastroenterology,
Mansoura University, Egypt.