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Volume 09 Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X Gastro Congress 2019
July 08-09, 2019
July 08-09, 2019 | Zurich, Switzerland
14th Euro-Global Gastroenterology Conference
Obesity is associated with increased risk for arterial and venous thromboembolism among inflammatory
bowel disease patients
Pearl Princess Uy1, Y Xiao1, D Wakefield1 and R Karagozian 2
1University of Connecticut Health Center, USA
2Saint Francis Hospital, USA
Introduction: There is an increasing prevalence of obesity worldwide, including recent studies indicating increasing
prevalence of obesity among inflammatory bowel disease (IBD) patients. There are mixed data regarding the impact
of obesity on IBD-related health outcomes. Obesity, defined by a body mass index of at least 30 kg/m2, is associated
with a pro-inflammatory state with elevated levels of C-reactive protein, tumor necrosis factor α and interleukin
6. IBD also predisposes individuals to thrombosis via up-regulation of prothrombotic factors and inhibition of
fibrinolysis. Currently, there is paucity of knowledge regarding obesity and the risk of thrombosis among IBD
patients. We aimed to determine the prevalence of arterial and venous thromboembolism (VTE) among obese and
non-obese hospitalized IBD patients.
Methods: Discharges in the Nationwide Inpatient Sample (NIS) data set from 2012 were analyzed to identify
Ulcerative colitis (UC) [ICD-9 556.0-556.9] and Crohn’s disease (CD) [ICD-9, 555.0-555.2, 555.9] patients with
obesity [ICD-9 278.00-278.01, V85.30-V85.45]. The incidence of arterial and venous thrombotic events and inpatient
mortality were compared between obese and non-obese IBD patients using chi-square analysis.
Results: A total of 20,860 UC patients were identified and 9.19% were noted to be obese (n=1,918). Chi-square
analysis demonstrated an increased prevalence of VTE that includes deep vein thrombosis and pulmonary embolism
(11.73% vs. 8.23%, p<0.0001) and arterial thrombosis that consists of cerebral and coronary artery thrombosis,
and myocardial infarction (12.15% vs. 10.43%, p=0.00215) among obese UC compared to non-obese UC patients.
Similarly, 8.38% of identified CD patients were obese (3,151 out of 37,582 patients). There was an increased
prevalence of VTE (11.87% vs. 7.66%, p<0.0001) and arterial thrombosis (9.39% vs. 7.48%, p=0.0002) among obese
CD in comparison to non-obese CD patients. Lastly, there was no difference in mortality between hospitalized obese
and non-obese patients with either UC (2.40% vs. 2.64%, p=0.5991) or CD (0.95% vs. 1.11%, p=0.4744).
J Gastrointest Dig Syst 2019, Volume 09