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Volume 09
Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X
Gastro Congress 2019
July 08-09, 2019
July 08-09, 2019 | Zurich, Switzerland
14
th
Euro-Global Gastroenterology Conference
Association between LINC00657 and miR-106a serum expression levels and susceptibility to colorectal
cancer, adenomatous polyposis and ulcerative colitis in Egyptian population
Essam Soliman
Fayoum University, Egypt
C
olorectal cancer (CRC) represented the second cause of mortality among cancer patients. Long noncoding
RNAs and microRNAs (miRNAs) serve as non-invasive biomarkers for CRC surveillance and introduce new
therapeutic approaches. LINC00657 and miR-106a expression levels play a pivotal role in CRC. This study included
190 Egyptian subjects and the expression levels of LINC00657 and miR-106a in serum were measured by using
quantitative real-time polymerase chain reaction. We found that upregulation of LINC00657 and downregulation
of miR-106a are significantly associated with the development of CRC. Also, a positive correlation was detected
between their serum levels. In addition, serum LINC00657 can distinguish adenomatous polyposis (AP) patients
and/or ulcerative colitis (UC) patients from controls. Also the miRNA-106a expression level discriminates AP but
not UC from healthy individuals. Our study cited new diagnostic biomarkers for CRC, AP and UC among Egyptians
in addition to be non-invasive screening tools for CRC in both healthy subjects and those having precancerous
lesions.
Biography
Essam Soliman has completed his education from Fayoum University, Egypt. He has published 8 papers in reputed journals. Currently he is working as an
Associate Director of GIT at Foyoum University. His research interest mainly lies in the fields of Topical Medicine and Liver.
essamtropical@gmail.comEssam Soliman, J Gastrointest Dig Syst 2019, Volume 09