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Volume 8 Journal of Gastrointestinal & Digestive System
ISSN: 2161-069X Gastro Congress 2018
August 20-21, 2018
August 20-21, 2018 | Rome, Italy
13th Euro-Global
Gastroenterology Conference
Gut bacteria and metabolism: Examining host-microbe cross talk in the disease state
Susan Joyce
APC Microbiome Ireland - University College Cork, Ireland
Our co-evolved gut microbiota confers beneficial mutualistic relationships both to the microbial residents and to human
health. Microbes can alter human produced metabolites and indeed produce and excrete their own compounds to act
locally or indeed systemically to elicit a response. In doing so, microbes can influence many different host processes including
immune function and signalling to impact human health. Two examples of such processes include the catabolism of fatty acids
and bile acid modification. The liver is the site for bile acid synthesis and conjugation, however, the gut microbiota is responsible
for the range of diversity of bile moieties. Bile acids, released into the GI tract, are MI cellular components, emulsifiers of fat,
liberators of fat soluble vitamins and they also influence microbial populations temporally and spatially depending on the gut
region, the pH and oxygen levels. Here, we have examined the microbial, metabolic and gut hormonal hallmarks of an Irish
cohort of IBD to include Crohn’s disease and ulcerative colitis (n=182). Our data indicate microbial and metabolic adjustments
of different severity between disease states relative to healthy volunteers and also points to altered gut function and signalling.
Biography
Susan Joyce graduated with a from NUI Maynooth in Biology and Mathematics and a research PhD in host-miocrobe interactions. She was awarded a Marie Curie
Fellowship to examine cis and trans acting factors affecting mRNA synthesis and microbial gene expression at the Ecole Normal Superieure, Paris which included a stint
at the Max Planck Institute, Berlin. Before returning to University College Cork, She was a postdoctoral scientist at Trinity College Dublin and the Univerity of Bath, UK.
Her main interest is in microbial genetic and biochemical systems that alter eukaryotic host signalling. Susan is currently a Lecturer in the School of Biochemistry and Cell
Biology and a funded Investigator in the APC Microbiome Institute as part of the Spoke 4 Host- Microbe Dialogue.
Susan Joyce, J Gastrointest Dig Syst 2018, Volume 8
DOI: 10.4172/2161-069X-C5-076