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conferenceseries
.com
Volume 7, Issue 3 (Suppl)
J Gastrointest Dig Syst, an open access journal
ISSN: 2161-069X
Gastro 2017
June 12-13, 2017
June 12-13, 2017 Rome, Italy
11
th
Global
GastroenterologistsMeeting
Esam Elshimi et al., J Gastrointest Dig Syst 2017, 7:3(Suppl)
DOI: 10.4172/2161-069X-C1-050
Natural history of chronic hepatitis C development and progression as a consequence of iron and HFE or
TfR1 mutations
Esam Elshimi, Wesam Saber Morad, Hala Hani El Said
and
Nermine Ahmed Ehsan
National Liver Institute, Egypt
Introduction & Aim
: Heavy iron overload is toxic to virtually all cells and tissues. There is growing evidence that only modest
amounts of iron in the liver may serve as a co-morbid factor to increase the severity and/or rate of progression of liver disease. Aim of
this study is to explore the role of iron, HFE mutations, and polymorphisms of the
TfR1
gene in the progression of chronic hepatitis
C infection and possible therapeutic implications of iron overload on interferon therapy of patients with chronic hepatitis C.
Methods
: From 3
rd
October 2012 to 6
th
January 2016, we studied 300 consecutive patients with chronic hepatitis C, correlating
clinical, laboratory, histopathological, and genetic data. Frequencies of genetic variations were compared with healthy controls.
Results
: HFEmutations were more common in patients than controls (25% vs. 11.7%, P=0.00006), and the C282Ymutation were more
common in patients than controls (38.0% vs. 48.0%, P=0.02). Patients carrying C282Y had higher mean hepatic iron concentrations
(P=0.02). Hepatic fibrosis was correlated with hepatic iron concentration (P=0.03). HFE and TfR1 polymorphisms bore detectable
relation to disease severity and to response to interferon therapy.
Conclusions
: Hepatic iron and HFE andTfR1mutations are co-morbid factors that increase progression of chronic hepatitis C and
decrease the response to interferon therapy.
Biography
Esam Elshimi is working at Menoufia University, Egypt. He is the recipient of numerous awards for his research works in related fields. His research interests reflect
in his wide range of publications in various national and international journals.
eelshimi@liver-eg.org