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Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal
Page 38
Notes:
Euro Toxicology 2016
October 24-26, 2016
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
Attenuation of adverse health effects of metallic nanoparticles with innocuous bioprotectors:
Mechanistic hypotheses and experimental results
I A Minigalieva1, B A Katsnelson 1, L I Privalova 1, M P Sutunkova 1, V B Gurvich1, O H Makeyev2, I E Valamina2, V Y Shur 3 and E V Shishkina3
1The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia
2Ural Medical University, Russia
3Ural Federal University, Russia
Especially high health risks associated with impacts of metallic and metal oxides nanoparticles (Me-NPs) contaminating
working environments of not only the emerging nano-industry but also of some long-existing traditional technologies
makes it necessary, along with keeping respective dangerous exposures as low as possible, to look for ways of increasing the
organism’s resistance to them (the “biological prophylaxis”). Theoretical premises of beneficial interventions in toxicokinetics
and toxicodynamics of Me-NPs are inferred from understanding general and specific key mechanisms of their adverse action
and on our previous experience in the field of such bio-protection against other toxics. Based on these premises, we proposed
several “bio-prophylactic complexes” (BPCs) comprising mainly pectin, some vitamins, glutamate, glycine, N-acetylcysteine,
omega-3 PUFA and different essential trace elements. Results of several in vivo experiments with NPs of metallic silver and of
copper oxide as well as with binary and trinary combinations of Me-NPs characteristic of workroom air pollution in different
industries have proved that, against the background of such BPCs’ oral administration, the pulmonary and systemic toxicity of
Me-NPs and even their genotoxicity can be markedly attenuated. Therefore, we recommend to further develop this vector of
nano-toxicological research. Our previous positive experience in organizing first a selective and then a large-scale biological
prophylaxis of adverse health effects of many other toxicants makes us expect that it would be no less practicable and effective
in the field of nano-toxicology as well.
I A Minigalieva et al., J Clin Toxicol 2016, 6:6(Suppl)