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Volume 7, Issue 4 (Suppl)
J Clin Exp Pathol, an open access journal
ISSN: 2161-0681
Euro Pathology 2017
August 02-03, 2017
13
th
EUROPEAN PATHOLOGY CONGRESS
August 02-03, 2017 Milan, Italy
Canine insulinoma: ACase Report
Otavio Monteiro
UNIFEOB School of Veterinary Medicine, Brazil
I
nsulinomas or beta cell tumors, are pancreatic insulin-secreting neoplasias which are rarely diagnosed in dogs. However, it
is recognized to be the most common islet of Langerhans cell tumors in dogs. Although cases have been reported in younger
dogs, insulinoma occurs most frequently in middle aged to older dogs with an average age of nine years³. An 11-year-old male
Poodle was presented to the Veterinary Hospital in São João da Boa Vista, SP, Brazil with polyphagia, history of rapid weight
gain in the last six months, episodic weakness, cyanotic mucous membranes and convulsions after exercise. Serum chemistry
performed showed sustained marked hypoglycemia (41-30 mg/dL). A complete blood count and serum biochemistry profile
were within reference ranges. An abdominal ultrasound and radiographs examination showed no significant changes. The
patient showed epilepticus status throughout internment. Hyperglycaemic therapy was unsuccessful and after eleven days of
treatment, the owners decided for euthanasia. Necropsy revealed mildly enlarged pancreas with 3 individual, hard, roughly
round white masses of about 0,5 cm in diameter. All tissues were submitted for routine histopathologic examination that
reveals monomorphic polygonal cells, typical of neuroendocrine packeting. Cells have moderate amounts of finely granular
eosinophilic cytoplasm, basilar or centrally located round nuclei, clumped chromatin, and a single prominent nucleolus.
Neoplastic beta cells secrete insulin independent of blood glucose concentration, resulting in persistent and unregulated
hypoglycemia. As a consequence, hypoglycemia of the central nervous system leads to the clinical signs of seizure and coma.
Biography
Otavio Monteiro is Brazilian born 25 year old Veterinary Medicine student currently coursing his fifth semester at UNIFEOB School of Veterinary Medicine in São
João da Boa Vista SP, Brazil. After concluding his high school in Philadelphia, PA returned to brazil to iniciate his studies in the veterinary branch. He has previously
published case reports and retrospective studies in the pathology area, and is now working on his first scientific initiation.
otaviomonteiro64@gmail.comOtavio Monteiro, J Clin Exp Pathol 2017, 7:4(Suppl)
DOI: 10.4172/2161-0681-C1-038