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conferenceseries
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Volume 7, Issue 4 (Suppl)
J Clin Exp Pathol, an open access journal
ISSN: 2161-0681
Euro Pathology 2017
August 02-03, 2017
13
th
EUROPEAN PATHOLOGY CONGRESS
August 02-03, 2017 Milan, Italy
Morphological features of changes of various types of grafts in patients who died after coronary
artery bypass graft surgery from isolated coronary heart disease and associated with hypertensive
disease
Ruzanna Petrosyan
Beirut Arab University, Lebanon
Objectives:
Vascular graft failure is one of the most common finding in patients undergoing coronary artery bypass graft
(CABG) surgery and still remains the major problem after surgery. The aim of the present study was to investigate features
of pathomorphological changes in different type of grafts after CABG in patients with isolated coronary artery disease and
associated with hypertensive disease.
Materials & Methods:
Histopathological study was performed on 207 fragments of autopsy sections of autoarterial and
autovenous grafts using light microscopy.
Results:
It is shown that the condition of the vascular wall is dependent on hemodynamics leading to degenerative changes of
the graft as a result of destructive and proliferative processes in the intima and the middle layer. Active replacement of smooth
muscle cells of the media by fibrous tissue and then connective tissues leads to thickness of the vascular wall, stenosis on one
hand and on the other hand development of unstable atheromatous plaques.
Conclusions:
Morphological changes of the venous grafts in patients had undergone CABG and had died after surgery from
coronary heart disease associated with hypertonic disease were more acute with more aggressive course of atherosclerotic
changes with diffuse proliferation of processes and formation of unstable plaques.
n.vanleersum@dica.nlJ Clin Exp Pathol 2017, 7:4(Suppl)
DOI: 10.4172/2161-0681-C1-038