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Volume 5, Issue 6(Suppl) J Infect Dis Ther, an open access journal
ISSN: 2332-0877 Euro Infectious Diseases 2017
September 07-09, 2017
Page 46
conferenceseries.com
September 07-09, 2017 | Paris, France
Infectious Diseases
6th Euro-Global Conference on
Huseyin Kayadibi, J Infect Dis Ther 2017, 5:6(Suppl)
DOI: 10.4172/2332-0877-C1-031
Clinical significance of the indirect biochemical markers for detecting liver fibrosis in adult patients
with chronic HCV infection
Hepatitis C virus (HCV) has been considered to be one of the main causes of the liver fibrosis. Estimation of the stage of liver
fibrosis is mandatory for the management of patients with HCV infection. Although liver biopsy is still the gold standard
diagnostic tool to assess the stage of liver fibrosis, it is not available to be performed for all patients, and has lots of complications,
as well as non-invasive tests may play a role in the evaluation of liver fibrosis. Moreover, the accuracy of liver biopsy is limited
due to the intra- and inter-observer variability and sampling errors. Therefore, the development of simple, cheap and accurate
biochemical markers is necessary to detect the liver fibrosis. Platelet count, AST to ALT Ratio, AST to platelet ratio index,
age platelet index, Pohl score, Forns index, FIB-4, hepascore, fibrometer and fibrotest are the most commonly used indirect
biochemical markers used for the detection of liver fibrosis. Instead of a single biochemical marker, use of the combinations
of these non-invasive biochemical markers for liver fibrosis may increase the diagnostic accuracy of the single biochemical
markers and may markedly reduce the need for liver biopsy. Therefore, use of these biochemical markers as an initial step
before the invasive and expensive procedures is important in routine clinical practice for the favor of patients.
Biography
Huseyin Kayadibi received a Degree in Medicine from the GATA School of Medicine (Turkey) in 2000. He is an Associate Professor in Medical Biochemistry at Hitit University
School of Medicine, where he is the Head of Medical Biochemistry. He worked at Pasarow Mass Spectrometry Laboratory, University of California Los Angeles in 2012 as a Visiting
Scholar. He has been a Co-investigator on NIH and other international projects about metabolomics, proteomic and lipidomic analysis. He is the Member of EFLM Working Group
Test Evaluation and IFCC Working Group Cerebrospinal Fluid Proteins. He has published more than 70 papers in peer reviewed journals. His research interests are non-invasive
assessment of liver fibrosis, separation techniques and mass spectrometry.
Huseyin Kayadibi
Hitit University School of Medicine, Turkey