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Volume 8, Issue 3 (Suppl) J Clin Exp Dermatol Res, an open access journal
ISSN: 2155-9554 Euro Dermatology 2017
June 07-08, 2017
June 07-08, 2017 Milan, Italy
16th European Dermatology Congress
Preventive effect of cacao extract onUVB-induced skinwrinkle formationvia inhibitionofDNAmethylation
Tae-Aug Kim, Aram Kim, Jina Choi, Jihwan Lee, Seung Hwa Baek and Donghyun Kim
CHA University, South Korea
C acao beans contain various bioactive phytochemicals that can attenuate or delay the onset of disease condition. However, the
effect of cacao powder (CP) on UVB-induced wrinkle formation and the molecular mechanisms responsible has not previously
been explored. Here, we report that oral administration of CP attenuates UVB-induced skin wrinkling by regulating genes involved
in dermal matrix production and maintenance. Transcriptome analysis revealed that 853 genes are down- or up-regulated with CP
supplementation, compared with UVB-irradiated mouse skin controls. CP elicited anti-wrinkle effects via inhibition of UVB-induced
MMP-1 expression in a human skin equivalent model and human dermal fibroblasts (HDFs). Inhibition of UVB-induced AP-1 via
CP supplementation is likely to affect the expression of MMP-1. In addition pattern-matched analysis of transcriptome and DMA
methylome provide many new signature molecules regulated by CP and UVB. CP specifically modulated the expression of profilin-1
and involucrin by suppression of their DNA methylation. These results suggest that cacao extract may offer a protective effect against
the photoaging process by epigenetic regulation of signature molecules, leading to an overall reduction in wrinkle formation
Biography
Tae-Aug Kim has completed his PhD at State University of New York at Buffalo, Buffalo, NY, USA, (1993). He moved to Cutaneous Biological Research Center
at Massachusetts General Hospital (MGH)/ Beth Israel Deaconess Medical Center (BIDMC)/Harvard Medical School (HMS), Boston. MA. USA, focusing on the
molecular mechanism of TGF signalling on skin development for his postdoctoral training (1993-1999). Then, he was appointed as Instructor at HMS/BIDMC,
continuing his research on neuronal degeneration (1999-2002). After he relocated to National Cancer Institute, Bethesda, MD, USA as a senior research fellow
(2002-2011), he has working on the role of epigenentic modification and heterochromatin structure on human cancer and DNA repair. He is currently Director of
Skin Biology Research Center , School of Medicine, CHA University, South Korea and is working on epigenetic regulation of skin aging and cancer using 3D skin
equivalent model.
Tae-Aug Kim et al., J Clin Exp Dermatol Res 2017, 8:3 (Suppl)
DOI:10.4172/2155-9554-C1-056