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Volume 7, Issue 4(Suppl)
J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460
Euro Dementia Care 2017
September 18-19, 2017
Dementia and Dementia Care
September 18-19, 2017 Dublin, Ireland
8
th
International Conference on
Ana Ivancheva et al., J Alzheimers Dis Parkinsonism 2017, 7:4(Suppl)
DOI: 10.4172/2161-0460-C1-028
Prion disease – The last diagnosis
Ana Ivancheva
and
Hakim Ghani
Mayo University Hospital, Ireland
A
73-year-old lady was referred to a neurologist after two geriatric consults due to deteriorating cognitive function, ataxia and
weakness. She was completely dependent in slightly over one year. From walking with a frame, she became wheelchair bound.
Her cognition continued to decline and could not feed herself due to apraxia. When assessed she was found to have rigidity, myoclonus
and left-right disorientation. Overall impression was that she had prominent extrapyramidal and cortical disease.
Diagnosis
: Due to rapid symptoms progression, typical MRI brain findings and highly specific CSF 14-3-3, S100B and RT-QuIC,
she was diagnosed with probable sporadic Creutzfeldt-Jakob disease(sCJD). Brain biopsy post-mortem would confirm the diagnosis.
Discussion
: SCJD has unclear mechanism of initial conformational change of prion protein. CJD has worldwide distribution, where
85% are sCJD and occurs at rate of 1 in 1,000,000 population per year. Mortality rate is less than 1 per million depending on country.
Researchers mention difficulties in ascertaining accurate incidence, prevalence and mortality rate due to under-reporting, under-
awareness and poor diagnostic capability. Possibly CJD is higher than thought due to misdiagnosis
Biography
Ana Ivancheva graduated from Medical University of Sofia in 2016. She has completed her internship in Sofia, Bulgaria. She is currently completing BST programme
in internal medicine at MUHl. She is an author in a medical textbook in Bulgaria and is currently pursuing her interest in academic writing.
anaivancheva@gmail.com