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conferenceseries
.com
Volume 8
Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460
Euro Dementia 2018
May 24-25, 2018
May 24-25, 2018 | Vienna, Austria
11
th
International Conference on
Alzheimers Disease & Dementia
Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae
Xiao Zhen Zhou
1,2,3
, Onder Albayram
1,2,3
, Asami Kondo
1,2,3
, Rebekah Mannix
4
, Colin Smith
5
, Cheng-Yu Tsai
1,2,3
and
Chenyu Li
1,2,3
1
Harvard Medical School
2
Beth Israel Deaconess Medical Center
3
Center for Life Science
T
raumatic brain injury (TBI) is characterized by acute neurological dysfunction and associated with the development of
chronic traumatic encephalopathy (CTE) and Alzheimer’s disease. We previously showed that cis phosphorylated tau
(cis P-tau), but not the trans form, contributes to tau pathology and functional impairment in an animal model of severe
TBI. Here we found that in human samples obtained post TBI due to a variety of causes, cis P-tau is induced in cortical
axons and cerebrospinal fluid and positively correlates with axonal injury and clinical outcome. Using mouse models of severe
or repetitive TBI, we showed that cis P-tau elimination with a specific neutralizing antibody administered immediately or
at delayed time points after injury, attenuates the development of neuropathology and brain dysfunction during acute and
chronic phases including CTE-like pathology and dysfunction after repetitive TBI. Thus, cis P-tau contributes to short-term
and long-term sequelae after TBI, but is effectively neutralized by cis antibody treatment. Our results state showed that axonal
injury and cis P-tau induction in clinical severe TBI; CSF cis P-tau correlates well with outcome in TBI patients; cis P-tau found
in deeper brain regions in CTE patients; cis mAb improves acute phase outcomes after ssTBI; cis mAb improves chronic phase
outcomes after ssTBI; delayed cis mAb administration improves outcomes after ssTBI; - cis mAb prevents CTE pathology and
dysfunction after rmTBI and also the efficacy of cis mAb in improving outcomes across studies.
xzhou@bidmc.harvard.eduJ Alzheimers Dis Parkinsonism 2018, Volume 8
DOI:10.4172/2161-0460-C3-043