euro-dementia-2018-posters-abstracts

Page 61

Notes:

conferenceseries

.com

Volume 8

Journal of Alzheimers Disease & Parkinsonism

ISSN: 2161-0460

Euro Dementia 2018

May 24-25, 2018

May 24-25, 2018 | Vienna, Austria

International Conference on

Alzheimers Disease & Dementia

Serum levels of high molecular weight adiponectin and leptin in elderly patients with dementia

Samer G Hanna, Marwa A Saad, Mohamed A Mehanna

and

Dalia A Alneily

Alexandria University, Egypt

Postgraduate Institute of Medical Education and Research, India

ementia is a progressive impairment of cognitive function, sufficient to cause functional decline. It may affect up to

28 million individuals worldwide; 30% of those older than 85 years. Adiponectin is a cytokine released by the adipose

tissue, present in the cerebrospinal fluid of human. It has important functions in the central nervous system. Leptin is another

cytokine that has implications in cognitive decline and dementia processes. The aim of the present study was to determine the

serum levels of adiponectin and leptin in elderly patients with dementia. 60 subjects aged 65 years and older were involved

and divided into two groups; Group (I): 40 demented patients, and Group (II): 20 age and sex matched healthy subjects as a

control group. Participants with dyslipidemia, hypertension, diabetes mellitus, chronic liver diseases, chronic kidney diseases,

thyroid disorders, or morbid obesity were excluded from the study. All participants were subjected to Mini-Mental State Exam

(MMSE) and Montreal Cognitive Assessment (MoCA) tests; serum adiponectin and leptin levels were measured. Serum

adiponectin was higher, while leptin levels were lower in demented patients. A significant negative correlation between serum

levels of adiponectin and both MMSE and MoCA scores, while a high positive correlation was noted between serum levels

of leptin and both MMSE and MoCA scores. We concluded that serum adiponectin and leptin were strongly associated with

dementia in elderly patients, which may help in understanding of its pathogenesis and emergence of new drugs for better

outcome of this devastating disease.

J Alzheimers Dis Parkinsonism 2018, Volume 8

DOI:10.4172/2161-0460-C3-043