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Volume 9
Journal of Clinical & Experimental Cardiology
ISSN: 2155-9880
October 22-24, 2018 | Rome, Italy
27
th
European Cardiology Conference
Euro Cardiology 2018
October 22-24, 2018
Cardiovascular diseases: Focus on endoplasmic reticulum stress and Nrf2 signalling
Chiara Mozzini
University of Verona, Italy
T
his presentation is intended primarily to summarize the understanding of the interrelated roles of endoplasmic reticulum
(ER) stress, oxidative stress and inflammation in cardiovascular diseases. Insults interfering with ER function lead to
the accumulation of unfolded and misfolded proteins in the ER. An excess of proteins folding in the ER is known as ER
stress. This condition initiates the unfolded protein response (UPR). When the UPR fails to control the level of unfolded
and misfolded proteins, ER-initiated apoptotic signalling is induced. Moreover, the role of the protective nuclear erythroid-
related factor 2 (Nrf2)/antioxidant-related element (ARE) and the activation of the pro-inflammatory nuclear factor-kappa
B (NF-kB) are analyzed. Oxidative stress, inflammation and ER stress are closely entwined phenomena. They are involved in
the pathogenesis of different cardiovascular diseases. Current literature data are presented, focusing on three topics of related
pathologies: atherosclerotic plaque, coronary artery disease and diabetes. This presentation provides a basic platform for study
and application to several other conditions in which oxidative stress, ER stress and inflammation are key features. Future
studies in this area may identify the most promising molecules to be investigated as common targets for cardiovascular disease.
Biography
Chiara Mozzini pursued her Medical Doctor Degree from the University of Brescia, Italy (2006). She is a Board Certified Specialist in Internal Medicine at the
University of Verona, Italy (2012). Section of Internal Medicine University of Verona, Italy Medical Doctor Degree University of Brescia (Italy). She received her
PhD certification in clinical and experimental medical sciences. She is an Adjunct Professor (Researcher of type A)- Section of Internal Medicine at the University
of Verona, Italy. Her research field of interest includes: atherosclerosis, cardiovascular diseases, coronary artery disease, diabetes, oxidative stress, endoplasmic
reticulum stress and ultrasound (cardiac-abdominal- vascular). Her H-index is 11.
Chiara Mozzini, J Clin Exp Cardiolog 2018, Volume 9
DOI: 10.4172/2155-9880-C10-116