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Volume 6, Issue 7(Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal
Page 19
Euro Biotechnology 2016
November 07-09, 2016
conferenceseries.com
November 07-09, 2016 Alicante, Spain
12th Euro Biotechnology Congress
Denis Spitzer, J Biotechnol Biomater 2016, 6:7(Suppl)
Large-scale continuous manufacturing of nano-cocrystal drugs and therapeutics
NS3E laboratory developed the Spray Flash Evaporation (SFE) for preparing energetic organic nanoparticles at industrial
scale. The energetic solution is kept in a pressurized tank separated from a vacuum chamber by a hollow cone nozzle,
used both to heat and spray the liquid. The instantaneous evaporation of the solvent originates from the combination of the
abrupt pressure drop and the high energy stored by the overheated solvent prior to nebulization. The flash evaporation leads
to small crystallites with narrow size distribution. The nanoparticles may be composed of single compounds, mixtures of
several substances or co-crystals. The idea to transport these findings to the medicine became evident. In this domain, co-
crystals are of critical importance as they enhance bioavailability and up-take by the human body of Active Pharmaceutical
Ingredients (API). Up to now, most used techniques are of batch nature and not able to give access in big amounts to nanosized
crystals or co-crystals of therapeutic interest. The SFE permits the continuous manufacturing of nanosized co-crystals, in large
amounts with a kinetic complying with the pharmaceutical industry’s requirements. The efficiency of SFE was shown by the
manufacturing of nano-cocrystals based on caffeine/oxalic acid (2/1) and caffeine/glutaric acid (1/1) with a mean particle size
of 60 and 100 nanometers respectively. SFE currently used to produce nano-cocrystals, offers other promising prospects at the
interplay between medicine and energetics that will be highlighted in this conference.
Biography
Habil. Denis SPITZER received his in physical chemistry in 1993 at the University Louis Pasteur of Strasbourg. He is the founding and current Director of the NS3E
Research Laboratory UMR 3208 ISL/CNRS/UNISTRA. He conducts research in continuous nanoscristallization processes of organic nanomaterials such as model
medicaments and energetic materials. He is the inventor of the SFE process. He is the author of more than 150 publications and scientific reports. He received
in 2013 the award of strategic thinking given by the French Homeland Minister, and more recently, in 2015, the « Grand Prix Lazare Carnot » award of the French
Academy of Science, for dual use research.
Denis Spitzer
Nanomateriaux pour les Systemes Sous Sollicitations Extremes, France