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conferenceseries.com
Volume 7, Issue 5 (Suppl) Epidemiology (Sunnyvale), an open access journal
ISSN: 2161-1165 Epidemiology 2017
October 23-25, 2017
EPIDEMIOLOGY & PUBLIC HEALTH
October 23-25, 2017 | Paris, France
6th International Conference on
NEW INSIGHTS ON CONGENITALANOMALY CASE ASCERTAINMENT USING PRIMARY
CARE DATA: THE BORN IN BRADFORD, MULTI-ETHNIC COHORT STUDY
Chrissy Bishopa,b, Dan Masonb, Peter Corryb, John Wrightb, Eamonn Sheridanb, Neil Smalla,b and Roger Parslowb,c
aUniversity of Bradford, UK
bBradford Institute for Health Research, UK
cUniversity of Leeds, UK
Background: In the UK Congenital Anomalies (CA) are a common cause of childhood death and disability; they are the most
common cause of infant death for children of Pakistani origin. The CA rate in Bradford is nearly twice the national average.
In the present study we linked children with CA in the Born in Bradford study (BiB) to General Practice (GP) data. We have
used this routine data to prospectively study late diagnoses of CA and to further describe associations with risk factors for CA.
Methods: We used questionnaire data on 11474 babies from BiB, a prospective birth cohort study of 13857 babies and their
families, for which recruitment took place between 2007 and 2011. CA cases were identified by linking cohort babies to GP
records, anomalies were classified according to European Surveillance of Congenital Anomalies (EUROCAT) guidelines and
coded using ICD-10. Children with one or more CA (n=708), were compared to those without CA (n=10766). We calculated
univariate and multivariate risk ratios (RRs) with 95% confidence intervals for various maternal risk factors.
Findings: Use of routinely collected GP data increased the ascertainment of children with CA. At age one, rates for CA were
376 per 10,000 live births but accounted for only 60% of diagnoses. 40% of diagnoses were made after age one, increasing
rates to 619 per 10,000 live births to age eight. Consanguinity was found to be a risk factor for anomalies in Pakistani mothers
(multivariate RR 1.89, 95% CI 1.51-2.39).
Interpretation: 98% of UK CA registrations occur before age 1 year; our data suggest this is leading to incomplete case
ascertainment. National registries should reconsider an age restriction of one for CA case ascertainment. More complete
case ascertainment would provide better information for commissioners and allow funding decisions to better reflect clinical
requirements.
Biography
Chrissy Bishop worked as an Occupational Therapist for 5 years, during which she developed interests in Public Health and Policy Research. She studied her MSc
in Professional Health and Social Care whilst working in the NHS, progressing her interests towards health determinants and epidemiology. She left the NHS to
study a second MSc in Epidemiology and Biostatistics at the University of Leeds, during which she was introduced to the Born in Bradford Project. On graduating
she was awarded a scholarship to study her PhD with Born in Bradford. Her special interests are pathways through care for children with complex healthcare needs.
Chrissy Bishop et al., Epidemiology (Sunnyvale) 2017, 7:5(Suppl)
DOI: 10.4172/2161-1165-C1-017