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Volume 7, Issue 5 (Suppl) Epidemiology (Sunnyvale), an open access journal
ISSN: 2161-1165 Epidemiology 2017
October 23-25, 2017
EPIDEMIOLOGY & PUBLIC HEALTH
October 23-25, 2017 | Paris, France
6th International Conference on
INVESTIGATING THE CAUSAL EFFECT OF SMOKING ON HAY FEVER AND ASTHMA: A
MENDELIAN RANDOMIZATION META-ANALYSIS IN THE CARTACONSORTIUM
Tea Skaabya
aResearch Centre for Prevention and Health, Denmark
Statement of the Problem: Observational studies on smoking and risk of hay fever and asthma have shown inconsistent
results. However, observational studies may be biased by confounding and reverse causation. Mendelian randomization uses
genetic variants as markers of exposures to examine causal effects.
Methodology & Theoretical Orientation: We examined the causal effect of smoking on hay fever and asthma by using the
smoking-associated single nucleotide polymorphism (SNP) rs16969968/rs1051730. We included 231,020 participants from 22
population-based studies.
Findings: Observational analyses showed that current vs never smokers had lower risk of hay fever (odds ratio (OR) =0.68,
95% confidence interval (CI): 0.61, 0.76; p<0.001) and allergic sensitization (OR =0.74, 95% CI: 0.64, 0.86; P<0.001), but
similar asthma risk (OR=1.00, 95% CI: 0.91, 1.09; P=0.967). Mendelian randomization analyses in current smokers showed
a slightly lower risk of hay fever (OR=0.958, 95% CI: 0.920, 0.998; P=0.041), a lower risk of allergic sensitization (OR=0.92,
95% CI: 0.84, 1.02; P=0.117), but higher risk of asthma (OR=1.06, 95% CI: 1.01, 1.11; p=0.020) per smoking-increasing allele.
Conclusion & Significance: Our results suggest that smoking may be causally related to a higher risk of asthma and a slightly
lower risk of hay fever. However, the adverse events associated with smoking limit its clinical significance.
Biography
Tea Skaaby is an experienced Researcher in epidemiological, population-based preventive medicine. Her scientific focus areas are micronutrient deficiencies and
other risk factors for chronic diseases including cardiovascular disease and cancer. The current study is part of a series of studies intended to investigate whether
repeated health examinations with screening of various risk factors in an unselected population can prevent long-term incidence of ischemic heart disease, stroke,
diabetes and mortality, etc.
Tea Skaaby, Epidemiology (Sunnyvale) 2017, 7:5(Suppl)
DOI: 10.4172/2161-1165-C1-017