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Volume 7, Issue 5 (Suppl) Epidemiology (Sunnyvale), an open access journal
ISSN: 2161-1165 Epidemiology 2017
October 23-25, 2017
EPIDEMIOLOGY & PUBLIC HEALTH
October 23-25, 2017 | Paris, France
6th International Conference on
THE RISK OF HEMOBLASTOSIS IN OFFSPRING OF RADIATION-DANGEROUS
PRODUCTION STAFF
Svetlana F Sosninaa, Nailya R Kabirova a, Mikhail E Sokolnikova and Pavel V Okatenkoa
aSouthern Urals Biophysics Institute, Russia
Statement of the Problem: Parental preconceptional exposure is considered as one of the potential risk factors for hemoblastosis
in offspring. Employees of Mayak Production Association (Mayak PA), the first nuclear cycle enterprise in Russia, constitute
a unique cohort for calculating the carcinogenic risk in offspring. The purpose of this study is to evaluate the contribution of
parental chronic preconceptional external gamma exposure to the risk of hemoblastosis in offspring.
Methodology & Theoretical Orientation: We conducted retrospective study using nested case-control approach. Source
cohort included all people who were born in the city of Ozersk located near Mayak PA or became residents during 1949-2009.
Cases were defined as incident of hemoblastosis occured in person under age 25 in 1949-2009 (n=81), controls were matched
on sex, year of birth, parent’s age at birth (n=324). The excess relative risk (ERR) was calculated per unit dose of external
gamma exposure with a 95% confidence interval using the EPICURE program module PECAN.
Findings: Acute leukemia prevailed in the structure of hemoblastoses. There was no significant dose-response found. The
ERR/Gy coefficients were insignificant both in the analysis of the accumulated maternal dose: ERR/Gy= -7.95 (<0; 178.8), and
while analyzing the accumulated paternal dose: ERR/Gy = -24.6 (<0; 153.9). Non-parametrical analysis by dose categories did
not show any elevated risk as well.
Conclusion & Significance: The dose dependence between prolonged preconceptional external gamma exposure of parents
and the risk of hemoblastosis in offspring was not revealed. However, a small number of cases of hemoblastosis in offspring up
to the age of 25 limit the strength of the findings. The presence of predisposition to neoplasms in offspring and the manifestation
of the effect in the form of solid cancer at older age cannot be excluded, which requires continued monitoring.
Biography
Svetlana Sosnina has extensive experience in practical healthcare as a pediatrician and Head of the pediatric department, experience in teaching medical
disciplines. Area of her scientific interests comprises epidemiology, pediatrics, oncology, preventive health care. On the basis of unique cohort of employees of the
Production Association Mayak Svetlana carries out a multifaceted assessment of health status in descendants of workers in radiation hazardous industries, as well
as the assessment of radiogenic risks. This will improve medical monitoring of children's health and the radiation safety of Mayak personnel.
Svetlana F Sosnina et al., Epidemiology (Sunnyvale) 2017, 7:5(Suppl)
DOI: 10.4172/2161-1165-C1-018