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conferenceseries

.com

Volume 7, Issue 1 (Suppl)

J Biotechnol Biomater

ISSN: 2155-952X JBTBM, an open access journal

March 20-21, 2017 Rome, Italy

&

15

th

World Congress on

2

nd

International Conference on

Biotechnology And Biotech Industries Meet

Enzymology and Molecular Biology

Enzymology & Mol. Biology 2017

Biotechnology Congress 2017

March 20-21, 2017

Mohammed F. EL-Shiekha, J Biotechnol Biomater 2017, 7:1(Suppl)

http://dx.doi.org/10.4172/2155-952X.C1.071

Molecular study on the potential therapeutic activity of novel nanocomposite on cancerous tumor bearing

mice

Mohammed F. EL-Shiekha

October 6 University, Egypt

N

anoparticles are making significant contributions in the development of new approaches of drug delivery in cancer and can

provide a platform for combined therapeutics with subsequent monitoring of response. Basic curcumin and zinc oxide (ZnO)

nanocomposites modified with vitamin C and CTAB have been exerting chemo-preventative activity against cancer in mice animal

model. The present results observed that nanocomposite have distinct effects on liver cell viability via killing cancer cells, while posing

no effect on normal cells (hepatocytes). The marked difference in cytotoxicity between cancer cells and normal cells suggests an

exciting potential for nanocomposite as novel alternatives to cancer therapy. Our molecular data showed that both mRNA and protein

levels of tumor suppressor gene

p53 were

upregulated and induce activity of DNA fragmentation in liver cells.

Biography

Mohammed F El-Shiekha has completed his PhD from the Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, Egypt. He is a Faculty

Member in the Department of Biochemistry and pharmacy in October 6 University, Egypt. He has published 6 papers in reputed journals.

mohammmedfetoh@yahoo.com