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Volume 7, Issue 1 (Suppl)
J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal
March 20-21, 2017 Rome, Italy
&
15
th
World Congress on
2
nd
International Conference on
Biotechnology And Biotech Industries Meet
Enzymology and Molecular Biology
Enzymology & Mol. Biology 2017
Biotechnology Congress 2017
March 20-21, 2017
Mohammed F. EL-Shiekha, J Biotechnol Biomater 2017, 7:1(Suppl)
http://dx.doi.org/10.4172/2155-952X.C1.071Molecular study on the potential therapeutic activity of novel nanocomposite on cancerous tumor bearing
mice
Mohammed F. EL-Shiekha
October 6 University, Egypt
N
anoparticles are making significant contributions in the development of new approaches of drug delivery in cancer and can
provide a platform for combined therapeutics with subsequent monitoring of response. Basic curcumin and zinc oxide (ZnO)
nanocomposites modified with vitamin C and CTAB have been exerting chemo-preventative activity against cancer in mice animal
model. The present results observed that nanocomposite have distinct effects on liver cell viability via killing cancer cells, while posing
no effect on normal cells (hepatocytes). The marked difference in cytotoxicity between cancer cells and normal cells suggests an
exciting potential for nanocomposite as novel alternatives to cancer therapy. Our molecular data showed that both mRNA and protein
levels of tumor suppressor gene
p53 were
upregulated and induce activity of DNA fragmentation in liver cells.
Biography
Mohammed F El-Shiekha has completed his PhD from the Department of Biochemistry, Faculty of Veterinary Medicine, Benha University, Egypt. He is a Faculty
Member in the Department of Biochemistry and pharmacy in October 6 University, Egypt. He has published 6 papers in reputed journals.
mohammmedfetoh@yahoo.com