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Volume 7, Issue 1 (Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal
Enzymology & Mol. Biology 2017
Biotechnology Congress 2017
March 20-21, 2017
Page 57
Notes:
conferenceseries.com
March 20-21, 2017 Rome, Italy
&
15th World Congress on
2nd International Conference on
Biotechnology And Biotech Industries Meet
Enzymology and Molecular Biology
Bromoperoxidase mimicking bromination catalysts
Haloperoxidases are enzymes that are able to catalyze the oxidation of halide ions by using hydrogen peroxide. Catalytic
activities of haloperoxidases have received great attention because of their capability to halogenate a variety of organic
compounds. Vanadium bromoperoxidase (V-BrPO), which is a naturally occurring enzyme in marine algae, is a kind of
haloperoxidase. V-BrPO catalyzes two-electron oxidation of the bromide ion in the presence of hydrogen peroxide, leaving a
bromonium cation-like species. V-BrPO has been demonstrated to perform the catalytic bromination of organic compounds.
Bromination reaction is one of the most fundamental reactions in organic synthesis, providing important precursors and
substrates in various coupling reactions. Conventional bromination reaction is performed by using hazardous and toxic
elemental bromine. Considerable efforts have been focused on developing a versatile bromination method with a bromide
ion as a bromide source instead of bromine. So, the V-BrPO mimicking bromination reaction systems induced by a vanadium
catalyst and hydrogen peroxide have attracted much attention. These catalytic systems, however, require a stoichiometric
amount of a strong oxidant to generate the bromonium-like species. A more practical catalytic bromination reaction system
without the use of hazardous reagents needs to be developed. From the view point of green chemistry perspective, molecular
oxygen is regarded as the best candidate for oxidants. We embarked upon the development of an environmentally-favorable
catalytic method for selective bromination of a wide range of substrates. In this presentation, bromoperoxidase mimicking
versatile and practical bromination catalytic systems by the combination of a commercially available inexpensive ligand-free
vanadium catalyst and a Brønsted acid or a Lewis acid under molecular oxygen will be described.
Biography
Toshiyuki Moriuchi received his Bachelor’s degree in 1991 and Doctoral degree in 1995 under the supervision of Professor Toshikazu Hirao, from Osaka University.
He became an Assistant Professor at Osaka University and was a Post-doctoral Fellow at California Institute of Technology with Professor Jacqueline K Barton
(1996-1997). He was promoted to the position of Associate Professor in 2004. His current research interests focuses on the development of novel artificial bio-
conjugated systems based on self-organization of biomolecules and redox-active π-conjugated systems for functionalized catalysts and materials. He received the
Inoue Research Award for Young Scientists in 1997 and HGCS Japan Award of Excellence 2011 in the year 2012.
Toshiyuki Moriuchi
Osaka University, Japan
Toshiyuki Moriuchi, J Biotechnol Biomater 2017, 7:1(Suppl)