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Ear, Nose and Throat Disorders
Volume 8 Otolaryngology: Open Access ENT Conference 2018
May 14-15, 2018
Page 15
Notes:
conferenceseries.com
May 14-15, 2018 Osaka, Japan
2nd International Conference on
Clinico-radiological and immunological profile of patients of chronic rhinosinusitis with nasal polyps
Nasal polyposis is a chronic inflammatory disease of the mucous membrane in the paranasal sinuses. Despite its high
prevalence and extensive research its pathogenesis has still not been clearly understood. One of the proposed mechanisms
isTh1/Th2 response toTh17/Treg mediated inflammatory process. MixedTh1 andTh2 cytokine pattern has been reported from
India. We examined the clinical profile and serum levels of T helper (Th) cell subsets (Th1, Th2 andTh17) cytokines in patients
of nasal polyposis. Hundred cases of nasal polyposis and 40 healthy controls were studied. Polyp tissue and blood samples
from these patients were collected. Serum IgE and cytokines (IL-17, IL-1β, IL-21, IL-2, IL-4, IL-27 and TGF-β) levels were
measured using ELISA. Statistical analysis was carried out using SPSS (version 20.0). Independent t-test data were expressed
as mean±SD. All the tests were two sided with the significance level at probability below 0.05. Patients and healthy volunteers
were compared in terms of age, male/female ratio and the presence or absence of allergy. The mean CT scores of the cases were
recorded to be 9.06±1.51. Interleukin (IL)-17, IL-1β, IL-21 and TGF-β were significantly high (p<0.05) whereas IL-2, IL-4 and
IL27 were downregulated in cases with nasal polyposis as compared to healthy controls. High level of IL-17 and its regulating
cytokines in nasal polyposis patients raises a concern in effective management and therapeutic recovery of these patients. Th17
may play an important role in regulating allergic inflammation and provides a new immunotherapeutic implication.
Biography
Neelima Gupta is a Professor of Otorhinolaryngology at the University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India. She joined the
medical college as a teaching faculty in 2002 and has a research and teaching experience of 15 years. She has more than 35 research publications to her credit and
is involved in patient care as well as teaching undergraduates and postgraduate students at her institution. Her special interests are rhinology, chronic rhinosinusitis
and olfaction.
Neelima Gupta
University College of Medical Sciences, India
Neelima Gupta, Otolaryngol (Sunnyvale) 2018, Volume 8
DOI: 10.4172/2161-119X-C1-024