dermatology-conference-2016_keynote

4 / 6

Volume 7 Issue 8(Suppl) J Clin Exp Dermatol Res
ISSN: 2155-9554 JCEDR, an open access journal
Page 28
Dermatology Conference 2016
November 28-29, 2016
conferenceseries.com
November 28-29, 2016 Melbourne, Australia
10th Asia-Pacific Dermatology Conference
Shaofeng Yan, J Clin Exp Dermatol Res 2016, 7:8(Suppl)
Application of molecular tools in diagnosis and treatment of cutaneous melanoma
Melanoma is one of the most aggressive types of skin cancer. Histopathological criteria sometimes may be inadequate
in differentiating difficult melanocytic lesions. Treatment for advanced melanoma cases still remains elusive. New
development in molecular testing technologies is useful for improving diagnosis. New therapeutic approaches based upon
a growing understanding of the underlying molecular abnormalities have been used in advanced malignant melanoma
recently. Single nucleotide polymorphism (SNP) microarray analysis can accurately detect copy number changes and aid in
improving differentiation of malignant melanoma from benign melanocytic proliferation. Next-generation sequencing (NGS)
technologies have enabled detection of key genetic mutations for targeted therapy. Here we share our experience of application
of SNP microarray analysis in differentiation of malignant melanoma from benign melanocytic proliferation. Furthermore
using NGS testing for a 50 gene panel, we have identified numerous variable mutations, which may represent potential targets
for future therapies in patients with advanced melanoma.
Biography
Shaofeng Yan has received her MD degree from Peking Union Medical College and PhD degree from University of Washington at Seattle. She has completed
Anatomic and Clinical Pathology Residency at Dartmouth Hitchcock Medical Center and a combined Harvard Dermatopathology Fellowship at Massachusetts
General Hospital, Brigham Women’s Hospital and Beth Israel Deaconess Hospital. She is currently the Director of Dermatopathology Section and Program Director
of Dermatolopathology Fellowship Program of the Department of Pathology at Dartmouth Hitchcock Medical Center.
Shaofeng Yan
Dartmouth Hitchcock Medical Center, USA