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Volume 2, Issue 2 (Suppl)
Dent Implants Dentures, an open access journal
ISSN: 2572-4835
Dental Medicine 2017
October 16-18, 2017
October 16-18, 2017 New York, USA
29
th
Annual World Congress on
Dental Medicine & Dentistry
Oral lymphomatoid papulosis type C: A diagnostic pitfall, often confused with T-cell lymphoma
Ziv Schwartz
SUNY Downstate College of Medicine, USA
E
osinophilic ulcer of the oral mucosa (EUOM) is a rare, benign, self-resolving lymphoproliferative disorder, which typically presents
with asymptomatic to mildly tender ulcers. Histological findings of EUOM are characterized by a polymorphic infiltrate with
many eosinophils often extending into the underlying muscle. Although this entity is well documented within the dental literature,
it is not well known to physicians. The pathogenesis of the condition is unclear, although reports dating back to 1997 suggest that at
least a subset of EUOM represents CD30 positive lymphoproliferative disorder (CD30+LPD). More specifically, the original report
and subsequent authors suggest that the patients fall on the spectrum of CD30+LPD most reminiscent of Lymphomatoid papulosis
(LyP) seen in the skin. This oral variant of LyP would be expected to have the same diverse morphologic spectrum as that seen in
cutaneous LyP. We present five EUOM patients whose biopsies showed an atypical lymphocytic infiltrate most compatible with
type C LyP, a histologically unique subset of LyP, reminiscent of the biopsy findings encountered in the reported case by Ficarra
and co-workers. (Ficarra, et al., 1997) In four of the five cases, the biopsies were interpreted by expert hematopathologists as an
aggressive form of peripheral T cell lymphoma resulting in recommendations to administer systemic chemotherapy to four of the
patients, the scheduling of one patient for induction therapy and transplantation before revision of the diagnosis, and administration
of chemotherapy to one of the patients. The natural clinical course of spontaneous regression refuted the original diagnoses as a
form of aggressive peripheral T cell lymphoma. Recognition of oral LyP is critical to avoid inadvertent exposure to potentially toxic
chemotherapeutic regimens intended for the treatment of high grade lymphoma.
Biography
Ziv Schwartz has completed his Master of Health Administration and his Undergraduate studies at Cornell University. Subsequently, he has worked as an Administrative
Fellow at Northwell Health. He is currently a third year Medical Student at SUNY Downstate College of Medicine.
ziv.schwartz@downstate.eduZiv Schwartz, Dent Implants Dentures 2017, 2:2 (Suppl)
DOI: 10.4172/2572-4835-C1-003