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Volume 8
Journal of Alzheimers Disease & Parkinsonism
Dementia 2018
December 13-15, 2018
Page 36
Notes:
December 13-15, 2018 Abu Dhabi, UAE
13
th
Annual Conference on
Dementia and Alzheimer's Disease
Fish oil treatment during chronic maternal hypoxia improve cognition in rat offspring
Zohreh Ghotbeddin, Maryam Ali Heydari, Kaveh Zhazaeel and Mohammad Reza Tabandeh
Shahid Chamran University of Ahvaz, Iran
Introduction & Aim:
Brain hypoxia is the common stressors during pregnancy is associated with fetal brain injury and delay
in brain development. This effect can cause cognitive and behavioral disruption into later childhood. Fish consumption during
pregnancy has positively effect on cognitive abilities. In this study, we studied the effect of fish oil treatment during chronic
maternal hypoxia on cognitive task in rat offspring.
Method:
Rats were divided into two groups including sham and hypoxic group. To create hypoxic condition, pregnant rats
were kept in hypoxic box on DPC 6-21 with 10% oxygen and 90% nitrogen intensity for three hours. Sham group was injected
with saline for the same period of time. At the end, passive avoidance memory was performed by shuttle box test.
Result:
Results indicated that chronic maternal hypoxia reduced delay time (p<0.05) and increased time spent in dark room
(p<0.05) in shuttle box test compared to the sham group.
Conclusion:
According to our results, chronic hypoxia in pregnancy disrupts passive avoidance memory in rat offspring.
Biography
Zohreh Ghotbeddin has completed PhD from Tarbiat Modares University, Iran. He is an Assistant Professor of Physiology in Shahid Chamran University of Ahvaz,
Iran. He has published more than ten papers in reputed journals.
Zohreh Ghotbeddin et al., J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C8-057