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Volume 8
Journal of Alzheimers Disease & Parkinsonism
Dementia 2018
December 13-15, 2018
Page 35
Notes:
December 13-15, 2018 Abu Dhabi, UAE
13
th
Annual Conference on
Dementia and Alzheimer's Disease
Investigation of expression patterns of neurological proteins in serum and cerebrospinal fluid of
patients suffering from neurodegenerative disorders
Ghulam Md Ashraf
1
and Asma Perveen
2
1
King Fahd Center for Medical Research-King Abdulaziz University, Saudi Arabia
2
Glocal University, India
R
ecent researches have shown neurological proteins to exhibit altered expression in patients suffering from Neuro
Degenerative patients (NDDs) like Alzheimer’s Disease (AD), Parkinson’s Disorder (PD), Vascular Dementia (VaD) and
Amyotrophic Lateral Sclerosis (ALS). Serum and Cerebro Spinal Fluid (CSF) of various NDD patients were collected and the
expression pattern of Galectins (Gal-1, Gal-3 and Gal-9) and Matrix Metalloproteinases (MMP-1, MMP-3 and MMP-9) was
investigated. Quantitative ELISA measured the concentration of these proteins and a comparative analysis using other tools
was done to understand their expression pattern. The findings of this work provided a definitive pattern of expression of Gals
and MMPs in NDDs, which in turn proclaim their role as potential biomarkers to monitor the progression of the NDDs. These
insights will in turn help in designing new and more promising therapeutics strategies for the NDDs.
Biography
Ghulam Md Ashraf is currently working as a Associate Professor in King Fahd Medical Research Centre, King Abdulaziz University. And he is his field of expertise
are Biochemistry and Neurology. He is also designated as the associate editor in Frontiers in Aging Neuroscience.
Ghulam Md Ashraf et al., J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C8-057