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.com
Volume 8
Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460
Dementia 2018
October 29-31, 2018
October 29-31, 2018 | Valencia, Spain
12
th
International Conference on
Alzheimer’s Disease & Dementia
Brain metabolic and functional aspects of frailty in elderly with mild cognitive impairments
Seong A Shin
1, 2
, Dong-Hyun Yoon
1
, Wook Song
1
, Jun-Young Lee
2
and
Yu Kyeong Kim
2
1
Seoul National University, Seoul, South Korea
2
SMG-SNU Boramae Medical Center, Seoul, South Korea
T
he presence of frailty in elderly population has been clearly linked to higher risks of cognitive impairments and even
dementia. Literature documented that physical frailty was associated with accelerated cognitive decline, involving
memory, perceptual speed and visuospatial cognitive systems. Our study aimed to investigate alterations in metabolic and
functional activity in patients with mild cognitive impairments (MCI) with frailty phenotypes defined according to Fried
criteria, and to explore cognitive domains affected by frailty in association with the alterations in the brain. Participants were
assessed for frailty status based on the presence of five phenotypic components according to Fried criteria, and 21 MCI without
frailty (robust; absence of any frailty components) and 27 age- and gender-matched MCI with frailty (at-risk; presence of
one or more components) underwent [18F] FDG PET and resting state fMRI (rs-fMRI) scans. Using Statistical Parametric
Mapping 12 software in Matlab 2014a, [18F] FDG PET images were spatially normalized to a standard space for voxel-wise
statistical analyses. rs-fMRI data was also preprocessed to examine local intrinsic functional activity using fractional amplitude
of low frequency fluctuations (fALFF) and regional homogeneity (ReHo) measures. Subtle metabolic and functional activity
changes between groups as well as the associations between the activity of clusters showing significant group differences and
the performance in cognitive function were assessed after controlling for age, gender and year of education. In at-risk group,
reduced metabolic activity was found in left precuneus and right dorsolateral prefrontal cortex (Figure 1). Increased fALFF was
found in left supplementary motor area (Figure 2A), while disruptions in ReHo were found in bilateral caudate, right lateral and
medial frontal cortex and superior temporal cortex in at-risk group (Figure 2B). The alterations were significantly correlated
with the performance in several cognitive functions including executive function, language and visuospatial function. Our
results support that the physical frailty in MCI may accelerate the cognitive deteriorations by affecting frontal and temporal
areas.
Biography
Seong A Shin has completed her undergraduate study, majoring in Neurobiology at Department of Biomedical Science from University of Auckland, New Zealand,
and is continuing her postgraduate study (as a PhD candidate) on neuroimaging topics in neurodegenerative diseases including dementia and Parkinson’s disease.
sshi082@gmail.comSeong A Shin et al., J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C7-055
Figure 1.
Reduced glucose metabolism in at-risk
group.
Figure 2.
Abnormal local functional activity in at-
risk group.
Notes: