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.com
Volume 8
Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460
Dementia 2018
October 29-31, 2018
October 29-31, 2018 | Valencia, Spain
12
th
International Conference on
Alzheimer’s Disease & Dementia
Protective effects of phycobiliprotein on streptozotocin induced behaviour and biochemical deficits in
experimental model of Alzheimer's disease
Madhunika Agrawal
1
, Yamini P
1
, Kanwaljit Chopra
1
and
Seema Bansal
2
1
University Institute of Pharmaceutical Sciences, Panjab University, India
2
Postgraduate Institute of Medical Education and Research, India
T
he present study was designed to explore the neuroprotective efficacy of a promising antioxidant and anti-inflammatory,
phycobiliprotein (PB) against intracerebroventricular (ICV) streptozotocin (STZ) induced cognitive impairment in rats.
STZ (3 mg/kg) was introduced in rats’ brains on 1st and 3rd day bilaterally, followed by treatment with PB or rivastigmine
for 28 days. Estimation of alteration in the behaviour of treated and untreated group of rats were done by Morris water
maze, elevated plus maze and open field test. Afterwards, rats were sacrificed, and brains were harvested for the evaluation
of various biochemical parameters in post mitochondrial supernatant fractions of cerebral cortex and hippocampus. The
levels of several oxidative stress (SOD, CAT, LPO) and inflammatory (TNF-α, NF-κB) biomarkers activity were analyzed
towards acetylchoinesterase and was also investigated by ChAT assay. The amelioration of ICV-STZ induced spatial learning
and memory impairment by PB could be associated partially to the down regulation of NF-κB activity and the mitigation of
expression of neuroinflammatory cytokines, along with modulation of cholinesterase, suggesting that PB may be explored
further as a potent candidate for Alzheimer’s disease therapy.
madhunika21@gmail.comJ Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C7-055