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conferenceseries
.com
Volume 7, Issue 6 (Suppl)
J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460
Dementia 2017
October 16-18, 2017
ALZHEIMER’S DISEASE & DEMENTIA
October 16-18, 2017 | Rome, Italy
9
th
International Conference on
GAPDH mRNA expression in blood of Moroccan AD cases
Nadia El Kadmiri
1,2
, Meryam El Khachibi
2
, Ilham Slassi
2,1
, Bouchra El Moutawakil
2,1
, Sellama Nadifi
2
and
Abdelaziz Soukri
3
1
IBN ZOHR University, Morocco
2
Hassan II University of Casablanca, Morocco
3
Hassan II University of Casablanca, Morocco
Introduction:
Proteomics studies have been conducted to identify proteins affecting the degree of neurodegeneration and
could contribute to discover and define predictive biomarker signatures for AD. Several studies have highlighted the high
affinity interactions between GAPDH - β-amyloid in Alzheimer disease. The aim of our study to assess the mRNA expression
of GAPDH in the blood of Moroccan AD cases.
Methods:
A quantitative Real Time PCR was performed to evaluate the mRNA expression of GAPDH in samples of AD cases
and healthy controls.
Results:
the mRNA expression level of GAPDH in AD cases was significantly different as compared to healthy controls (P<
0.05). Conclusion: Our results reveal that GAPDH undergoes several modifications in neurodegeneration mechanism, that
affect its chemical structure and its biological activity, which could contribute as a biomarker for AD.
elkadmiri1979@gmail.comNadia El Kadmiri et al., J Alzheimers Dis Parkinsonism 2017, 7:6(Suppl)
DOI: 10.4172/2161-0460-C1-033