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conferenceseries.com
Volume 7, Issue 6 (Suppl) J Alzheimers Dis Parkinsonism, an open access journal
ISSN: 2161-0460 Dementia 2017
October 16-18, 2017
ALZHEIMER’S DISEASE & DEMENTIA
October 16-18, 2017 | Rome, Italy
9th International Conference on
Neuroinflammation &Alzheimer’s disease
Mai Mwafy1, 2, Paul Morgan2, Shelley Allen1 and Patrick Kehoe1
1Bristol School of Medicine, UK
2Cardiff University, UK
Neuroinflammation is a common feature of Alzheimer’s disease pathology, which is characterized by the presence of
reactive astrocytes and activation of the microglia (the brain’s resident macrophages), as well as increased expression of
pro-inflammatory cytokines & complement system activation. Amyloid beta protein accumulation in the brain of Alzheimer’s
disease patients is the activator of the complement system and leads to glial cells activation and subsequent release of neurotoxic
substances and free oxygen radicals. We are studying different aspects of neuroinflammation in a cohort of two groups “post-
mortem human brain tissue” of Alzheimer’s disease and age matched controls in different brain areas including frontal and
temporal cortices to highlight the role of innate immunity in the disease and if it can be considered as potential targets for
treating Alzheimer’s disease.
Biography
Mai Mwafy is currently a PhD student in University of Bristol, Dementia Research Group, also work in Infection & Immunity as a collaborator in Cardiff University, Mai
has completed her Master’s Degree in Medical Microbiology & Immunology in Egypt, Faculty of Medicine Tanta University in 2013. Funded by: Newton- Mosharafa
fund British Council in Egypt in collaboration with the Egyptian Government awarded 2015, and ARUK small grant awarded 2017.
Mai Mwafy et al., J Alzheimers Dis Parkinsonism 2017, 7:6(Suppl)
DOI: 10.4172/2161-0460-C1-034