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Volume 7, Issue 6 (Suppl)
J Gastrointest Dig Syst, an open access journal
ISSN: 2161-069X
Page 57
December 07-08, 2017 Madrid, Spain
&
13
th
International Conference on Clinical Gastroenterology & Hepatology
2
nd
International Conference on Digestive Diseases
CO-ORGANIZED EVENT
Periodontal and inflammatory bowel diseases: Is there evidence for complex pathogenic interactions?
Carlos Marcelo Figueredo
and
Ronaldo Lira-Junior
Rio de Janeiro State University, Brazil
P
eriodontal disease and inflammatory bowel disease (IBD) are both chronic inflammatory diseases and their pathogenesis is
mediated by a complex interplay between a dysbiotic microbiota and the host immune-inflammatory response, influenced
by genetic and environmental factors. This review aimed to provide an overview of the evidence dealing with a possible
pathogenic interaction between periodontal disease and inflammatory bowel disease. The prevalence of periodontal disease
seems to be increased in patients with IBD when compared to healthy controls, probably due to a changed oral microbiota
and a higher inflammatory response. Moreover, the induction of periodontitis seems to result in gut dysbiosis and altered gut
epithelial cell barrier function, which might contribute to the IBD pathogenesis. Considering the complexity of periodontal
and inflammatory bowel diseases, and the coexistence of both, it is very challenging to comprehend the possible pathways
involved in both diseases. In conclusion, this review points out to a complex pathogenic interaction between periodontal and
inflammatory bowel diseases, in which one diseasemight alter the composition of themicrobiota and increase the inflammatory
response related to the other. However, we still need more data derived from human studies to confirm results from murine
models. Thus, mechanistic studies are warranted to clarify this possible bidirectional association.
cmfigueredo@hotmail.comJ Gastrointest Dig Syst 2017, 7:6(Suppl)
DOI: 10.4172/2161-069X-C1-059