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Journal of Chromatography & Separation Techniques | Volume: 09
8
th
World Congress on Chromatography
September 13-14, 2018 | Prague, Czech Republic
Polymer Science and Technology
4
th
International Conference on
Joint Event on
&
Vakhtang Barbakadze
Tbilisi State Medical University,
Georgia
T
he caffeic acid-derived biopolymers from medicinal plants comfrey and
bugloss were isolated which represent a new class of natural polyethers.
According to
13
C-,
1
H-NMR, APT, 2D heteronuclear
1
H/
13
C HSQC, 1D NOE and
2DDOSY experiments the polyoxyethylene chain is the backbone of the polymer
molecule. 3,4-Dihydroxyphenyl and carboxyl groups are regular substituents
at two carbon atoms in the chain. The repeating unit of this regular polymer
is 3-(3,4-dihydroxyphenyl)-glyceric acid residue. Thus, the structure of natural
polymer was found to be poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene]
or poly[3-(3,4-dihydroxyphenyl)glyceric acid] (PDPGA). Then basic monomeric
moiety of this polymer 3-(3,4-dihydroxyphenyl)glyceric acid was synthesized via
Sharpless asymmetric dihydroxylation of trans-caffeic acid derivatives using
a potassium osmium catalyst. Besides, methylated PDPGA was obtained via ring
opening polymerization of 2-methoxycarbonyl-3-(3,4-dimethoxyphenyl)oxirane
using a cationic initiator. PDPGA is endowed with intriguing pharmacological
activities as immunomodulatary (anticomplementary), antioxidant, anti-
inflammatory, burn and wound healing and anticancer properties. PDPGA and
its synthetic monomer exerted anticancer activity
in vitro
and
in vivo
against
androgen-dependent and androgen -independent human prostate cancer (PCA)
cells via targeting androgen receptor, cell cycle arrest and apoptosis without
any toxicity, together with a strong decrease in prostate specific antigen level in
plasma. However anticancer efficacy of PDPGA against human PCA cells is more
Vakhtang Barbakadze, J Chromatogr Sep Tech 2018, Volume: 09
DOI: 10.4172/2157-7064-C2-042
Biopolymer fromMedicinal Plants its Synthetic Monomer and theirAnticancer Efficacy
effective than its synthetic monomer. Methylated PDPGA did not show any activity against PCA. Overall, this study identifies
PDPGA as a potent agent against PCA without any toxicity, and supports its clinical application.
Biography
Vakhtang Barbakadze has completed his Ph.D and D.Sci. in 1978 and 1999 from Institute of Organic Chemistry, Moscow, Russia and Institute of Biochemistry and
Biotechnology, Tbilisi, Georgia, respectively. He is the head of Department of plant biopolymers and chemical modification of natural compounds at the Tbilisi State
Medical University Institute of Pharmacochemistry. 1996 and 2002 he has been a visiting scientist at Utrecht University, The Netherlands, by University Scholarship
and The Netherlands organization for scientific research (NWO) Scholarship Scientific Program, respectively. He has published more than 96 papers in reputed
journals..
v_barbakadze@hotmail.com