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Volume 7, Issue 3 (Suppl) J Obes Weight Loss Ther, an open access journal
ISSN: 2165-7904 Childhood Obesity & Bariatric Surgery 2017
June 12-13, 2017
June 12-13, 2017 Rome, Italy
& Childhood Obesity and Nutrition
10th International Conference on
Metabolic and Bariatric Surgery
2nd International Conference on
JOINT EVENT
The effect of the FTO rs9939609 on anthropometrical measurements in female adolescents with overweight
and obesity
Tatyana Bairova, Ekaterina A Sheneman, Kseniia D Ievleva and Lubov V Rychkova
Scientific center for family health and human reproduction problems, Russian Federation
Statement of the Problem: Among the causes of obesity an important role is played by the heredity. The FTO is one of the genes
associated with obesity and body mass fat. And polymorphism rs9939609 of this gene located in the first intron (the code is W=A/T)
appears the most significant.
Methodology & Theoretical Orientation: The study included total of 128 Caucasian female adolescents (average age 15.86±1.02)
living in Eastern Siberia (Irkutsk region, Russia). SDS BMI, % of body mass fat was measured. 59 girls were included in group with
normal weight (SDS BMI 0.84±0.55) and 69 girls were included in group with overweight and obesity (SDS BMI 2.52±0.72). Genomic
DNA was extracted from EDTA-treated whole blood by commercial kits (DNA-Sorb-B, AmpliSens, Russia). Genotyping of the FTO
rs9939609 was performed using polymerase chain reaction in real time with DT-Prime cycler (DNA-technology, Russia). Statistical
analysis was performed by soft “STATISTICA8.0”.
Findings: A-allele frequency was 40% in control group and 49% was in group with overweight and obesity (р=0.223). Comparisons of
SDS BMI and percent of body mass fat stratified by FTO rs9939609 genotypes are shown in table 1. We found the significant increase
of SDS BMI in carriers of A-allele in group with overweight and obesity. There is no association in group with normal weight.
Conclusion & Significance: Thus, carrier of the A-allele of FTO rs9939609 are associated with higher meaning of SDS BMI in female
adolescents with overweight and obesity, living in Eastern Siberia.
Biography
Tatyana Bairova completed her graduation at Tomsk Medical Universitety as a pediatrician and; post-graduation at Scientific Centre for Family Health and Human
Reproduction Problems (SC FHHRP, Irkutsk, Russian Federation) where she is a specialist and a researcher.
Tatyana Bairova et al., J Obes Weight Loss Ther 2017, 7:3 (Suppl)
DOI: 10.4172/2165-7904-C1-046