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conferenceseries
.com
Volume 8
Journal of Obesity & Weight Loss Therapy
ISSN: 2165-7904
Childhood Obesity 2018
March 15-16, 2018
March 15-16, 2018 | Barcelona, Spain
11
th
International Conference on
Childhood Obesity and Nutrition
Evaluating the expression of known pro-inflammatory and obesity markers in prostate cancer
Maya Barbour, O’Quan Cross, Timothy Green, Shanora Brown
and
Ashley Knowell
South Carolina State University, USA
I
n the United States, childhood obesity has been a growing epidemic with, 1/3 of US children considered overweight or
obese. The increased number of overweight and obese children can be linked to several factors including nutrition and
social economic status. Households that do not have access to healthy, nutritious foods are significantly more likely to be obese
earlier in life than other children. Obesity in children can lead to numerous health complications such as diabetes, high blood
pressure, chronic inflammation and carcinogenesis. African American minorities are more likely to be diagnosed and die from
one of the various forms of cancer. Therefore, eliminating or reducing preventable risk factors such as unhealthy nutrition and
childhood obesity could have important implications for reducing clinical manifestations of adult cancer outcomes. In order to
understand the implication of inflammation in the participants, we first analyzed the expression of the inflammation biomarker
in prostate cancer cells, used as our baseline data. The pro-inflammatory markers and obesity related genes investigated include
adiponectin, leptin, SAA1 /2, interleukin 1 and 6. The transcriptional levels of pro-inflammatory genes were measured by
quantitative real-time polymerase chain reaction. The results indicated that the expressions of chronic inflammation markers
were increased in cancer DNA as compared to normal DNA. Overall reducing childhood obesity and pro-inflammatory diets
while increasing physical activity and access to healthy foods are beneficial in the reduction of cancer risk and will serve as
preventive measures for early-stage onset of adult cancers.
Biography
Maya Barbour is a senior Biology Major at South Carolina State University from Charleston, South Carolina. She has plans of attending graduate school. She
has been actively engaged in research for the past four years. O’Quan Cross is a senior Nutrition Major at South Carolina State University from Greenville, South
Carolina. He has plans to pursue a Master degree in Nutrition or Food Science. He has been actively engaged in research for the past four years.
Maya Barbour et al., J Obes Weight Loss Ther 2018, Volume 8
DOI: 10.4172/2165-7904-C1-057