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conferenceseries.com
Volume 8 Journal of Obesity & Weight Loss Therapy
ISSN: 2165-7904 Childhood Obesity 2018
March 15-16, 2018
March 15-16, 2018 | Barcelona, Spain
11th International Conference on
Childhood Obesity and Nutrition
Analyzing the role of high pro-inflammatory diets and childhood obesity in the risk of adult
carcinogenesis in South Carolinian children
Ashley E Knowell and Shanora Brown
South Carolina State University, USA
In the United States, childhood obesity has been a growing epidemic with, 1/3 of US children considered overweight or
obese. This increased number can be linked to several factors including nutrition and social economic status. Households
that do not have access to healthy, nutritious foods are significantly more likely to be obese earlier in life. Obesity in children
can lead to numerous health complications such as diabetes, high blood pressure, chronic inflammation and carcinogenesis.
African American is more likely to be diagnosed and die from some forms of cancer. Therefore, eliminating or reducing
preventable risk factors such as unhealthy nutrition and childhood obesity could have important implications for reducing
clinical manifestations of adult cancer outcomes. Areas of South Carolina, such as the I-95 Corridor, have a long history of
being under-developed which contribute to numerous problems such as obesity, poverty and sub-par health care. We have
enrolled SC children from varying degrees of rurality to determine if obesity and/or high-fat pro-inflammatory diets contribute
to increased levels of pro-inflammatory markers and obesity related genes to include: Adiponectin, leptin, SAA1 /2, Interleukin
1 and 6. Subjects will be randomized into obese and non-obese groups based on BMI guidelines. The transcriptional levels of
pro-inflammatory genes will be measured by quantitative RT-PCR. Reducing childhood obesity and pro-inflammatory diets
are beneficial in the reduction of cancer risk and will serve as preventive measures for early-stage onset of adult cancers. Data
analysis on the limited sample set is ongoing. Results will be presented during the conference.
Biography
Ashley E Knowell is investigating the role of childhood obesity as a risk factor for adult cancers. The ultimate goal of the project is to provide families with the
necessary tools and information to establish healthy nutritional habits; reduce childhood obesity and; ultimately reduce adult cancer risk among South Carolinian
children. Her research interests also include tumor suppressors, cell death and the development, progression, and treatment of cancer in African-Americans and
South Carolinians. She completed her Graduation from Clark Atlanta University.
Shanora Brown has actively been involved in the study of prostate cancer, molecular mechanisms of tumor progression as well a genetic factors contributing to
the disparities in cancer among diverse populations. Her current research focus is investigating and understanding the link between nutrition and childhood obesity
as a risk factor for adult carcinogenesis in South Carolinian children. Ultimately, eliminating or reducing preventable risk factors such as unhealthy nutrition and
childhood obesity could have important implications for reducing clinical manifestations of adult cancers, such as breast and prostate.
Ashley E Knowell et al., J Obes Weight Loss Ther 2018, Volume 8
DOI: 10.4172/2165-7904-C1-057