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Volume 9 Journal of Chemical Engineering & Process Technology Catalysis 2018
September 05-06, 2018
September 05-06, 2018 Tokyo, Japan
5 th World Congress on
Catalysis and Chemical Engineering
Isiaka A Owolabi et al., J Chem Eng Process Technol 2018, Volume 9
DOI: 10.4172/2157-7048-C2-015
A new type of amino amide organocatalyzed enantioselective crossed aldol reaction of ketones with
aromatic aldehydes
Isiaka A Owolabi1, Madhu Chennapuram 1, Chigusa Seki1, Yuko Okuyama2, Eunsang Kwon3, Koji Uwai1 and Hiroto Nakano1
1Muroran Institute of Technology, Japan
2Tohoku Medical and Pharmaceutical University, Japan
3Tohoku University, Japan
Anew type of amino amide organocatalysts A was designed and synthesized from commercially available amino acids
and polycyclic aromatic amines. The prepared multifunctional organocatalysts A explored as a new class of catalysts
with distinctive properties such as easy synthesis, stable in air, and the potential for convenient alteration of the steric sites.
Their catalytic activities were examined in enantioselective crossed aldol reaction of various acyclic and cyclic ketones 2 with
aromatic aldehydes 3 to afford the corresponding chiral anti-aldol adducts 4 that is a versatile precursor for the synthesis of
chiral biologically active compounds and drug molecules.
Biography
Isiaka Alade Owolabi received his MTech. degree in 2015 from Tshwane University of Technology, Pretotia South Africa. He later joined the Graduate School of
Engineering, Synthetic Organic Chemistry Laboratory at Muroran Institute of Technology as a Ph.D. student under supervision of Prof. Hiroto Nakano in 2016. His
research interest is organocatalytic asymmetric organization.