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Volume 3
Journal of Cancer Diagnosis
Cancer Diagnostics Conference 2018
August 15-16, 2018
Page 12
conference
series
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August 15-16, 2018 Singapore
International Conference on Cancer Research & Diagnostics
&
16
th
Asia Pacific Biotechnology Congress
Joint Event on
Novel exosome proteins as potential biomarkers for early detection of lung cancer
L
ung cancers are often diagnosed at advanced stages with concomitant poor prognosis, making it the leading cause of cancer
mortality worldwide. Herein, we aim to validate a panel of protein biomarkers identified from tumor cell-derived exosomes in
liquidbiopsies as diagnostic biomarkers for lung cancer. Biomarker candidateswere identifiedbyquantitative proteomics analyses.
Verification and validation of exosomal candidates were performed by western blot and ELISA, respectively. The diagnostic
performance for early detection of non-small-cell lung carcinoma was assessed using Receiver Operating Characteristic (ROC)
curve analyses. Compared to current cancer biomarker, CEA, several novel exosome proteins were discovered to have greater
diagnostic value in lung cancer. Importantly, these exosome proteins and their signatures demonstrated excellent diagnostic
performance in the early detection of lung cancer. Hence, the promising results derived from our exosome biomarker studies
warrant a large-scale clinical trial.
Biography
Lingzhi Wang is a Senior Research Scientist at Cancer Science Institute of Singapore and an Assistant Professor in the Department of Pharmacology of Yong Loo
Lin School of Medicine, National University of Singapore (NUS). He has obtained his PhD in Pharmacology in 2008 and won PhD Graduate Research Excellence
Award from American Association of Pharmaceutical Scientists (AAPS) Annual Meeting, USA. He has published more than 70 research papers. He also has been
serving as an Editorial Board Member of several peer reviewed scientific publications.
csiwl@nus.edu.sgLingzhi Wang
National University of Singapore, Singapore
Lingzhi Wang, J Cancer Diagn 2018, Volume 3
DOI: 10.4172/2476-2253-C1-001